Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets
Artikel i vetenskaplig tidskrift, 2009

Four different HPMC batches were characterized to investigate properties related to crit. functionality for their use in hydrophilic matrix tablets. In this study, the HPMC batches were chem. characterized and correlated to the behavior of pure HPMC tablets. Parameters such as the mol. wt., viscosity, intrinsic viscosity and radius of gyration were kept in a rather limited range, which resulted in a weak correlation to polymer release and degree of swelling. The hydrophilic/hydrophobic character of the HPMC samples was elucidated by the degree of substitution and by the clouding behavior, where an increased hydrophilicity increased the tablet swelling. This phenomenon was interpreted in a refined model for water transport into HPMC tablets. A five times slower polymer release and a considerably larger degree of swelling were found for one batch of HPMC tablets compared to the others, although the characterized av. polymer parameters were in the same range. However, the conformation plot displayed a fraction with compact aggregates. In conclusion, the existence of aggregates in aq. soln. seems to perturb the functionality of HPMC tablets and it seems important to understand and characterize these aggregates to fully predict the polymer release and swelling of HPMC tablets.

Tensile strength

Polymers Role: PRP (Properties)

THU (Therapeutic use)

Particle size distribution

HPMC polymer swelling release hydrophilic matrix tablet

Swelling

Dissolution

Radius of gyration

Viscosity (crit. polymer properties for polymer release and swelling of HPMC matrix tablets)

USES (Uses) (crit. polymer properties for polymer release and swelling of HPMC matrix tablets)

Pharmaceutical tablets

Molecular weight

BIOL (Biological study)

Cloud point

Hydrophilicity

Författare

Anna Viridén

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

Bengt Wittgren

AstraZeneca AB

Anette Larsson

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

European Journal of Pharmaceutical Sciences

0928-0987 (ISSN)

Vol. 36 297-309

Ämneskategorier

Farmaceutisk vetenskap

DOI

10.1016/j.ejps.2008.10.021

PubMed

19038336