Influence of Different Polymer Types on the Overall Release Mechanism in Hydrophilic Matrix Tablets
Artikel i vetenskaplig tidskrift, 2009

The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic emicrystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grades in different ratios were determined by using a modified USP II method and a SEC-rI chromatography system. The results showed that independent of polymer type: (i) plots of the release versus time had similar shapes, (ii) the release of long and short polymer chains was equal and no fractionation occurred during the release and (iii) the release rate could be related to the average intrinsic viscosity of the polymer mixtures. This confirms the hypothesis that the release rate can be related to a constant viscosity on the surface of the hydrophilic matrix tablet and that it is valid for all the investigated polymers. © 2009.

Författare

A. Körner

SCA

Lennart Piculell

Lunds universitet

Frida Iselau

AstraZeneca AB

Bengt Wittgren

AstraZeneca AB

Anette Larsson

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

SuMo Biomaterials

Molecules

1420-3049 (ISSN)

Vol. 14 8 2699-2716

Ämneskategorier

Farmaceutisk vetenskap

DOI

10.3390/molecules14082699

Mer information

Senast uppdaterat

2018-09-06