The Carotid Artery Plaque Size and Echogenicity are Related to Different Cardiovascular Risk Factors in the Elderly
Artikel i vetenskaplig tidskrift, 2009

Carotid plaques can be characterised by ultrasound by size and echogenicity. Both size and echogenicity are predictors of cardiovascular events. The aim of this study was to examine whether traditional risk factors and markers of inflammation and oxidation were associated with plaque size and echogenicity. Computerised analysis of carotid plaque size and echogenicity (grey scale median, GSM) were performed by ultrasound in a population-based health survey in 1,016 subjects aged 70 years (PIVUS study). Information on cardiovascular risk factors was collected, together with markers of inflammation and oxidation. Increased Framingham risk score, systolic blood pressure, higher BMI and decreased HDL, lower glutathione levels were related to echolucent plaques. Previous or present smoking was common with significantly more pack-years related to the echorich plaques. Plaque size was associated with increased Framingham risk score, systolic blood pressure, blood glucose levels, smoking, ApoB/A1 ratio, OxLDL, TNF alpha, HOMA insulin resistance, leucocyte count, decreased BCD-LDL and low levels of l-selectin. Low HDL, increased BMI and decreased glutathione levels were associated with the echolucency of carotid plaques, implying metabolic factors to play a role for plaque composition. Markers of inflammation were related to plaque size alone, implying inflammation to be predominantly associated with the amount of atherosclerosis. These results suggest that plaque size and echogenicity are influenced by different risk factors.

men

general-population

Lipids

count

Carotid artery

atherosclerosis

Oxidation

prevalence

Atherosclerosis

Plaque

leukocyte

Ultrasound

uppsala

seniors pivus

Risk factor

density-lipoprotein cholesterol

independent predictor

tromso

coronary-heart-disease

Författare

J. Andersson

Akademiska Sjukhuset

J. Sundstrom

Akademiska Sjukhuset

L. Kurland

Akademiska Sjukhuset

Tomas Gustavsson

Signaler och system, Signalbehandling och medicinsk teknik, Digitala bildsystem och bildanalys

Johannes Hulthe

Wallenberg Lab.

AstraZeneca Sweden

A. Elmgren

AstraZeneca Sweden

K. Zilmer

University of Tartu

M. Zilmer

University of Tartu

L. Lind

Akademiska Sjukhuset

Lipids

0024-4201 (ISSN)

Vol. 44 397-403

Ämneskategorier

Kardiologi

DOI

10.1007/s11745-009-3281-y