Zebrafish: gaining popularity in lipid research
Artikel i vetenskaplig tidskrift, 2010

Zebrafish are an increasingly popular vertebrate model organism in which to study biological phenomena. It has been widely used, especially ill developmental biology and neurobiology, and many aspects of its development and physiology are similar to those of mammals. The popularity of zebrafish relies on its relatively low cost, rapid development and ease of genetic manipulation. Moreover, the optical transparency of the developing fish together with novel imaging techniques enable the direct visualization of complex phenomena at the level of the entire organism. This potential is now also being increasingly appreciated by the lipid research community. In the present review we summarize basic information on the lipid composition and distribution in zebrafish tissues, including lipoprotein metabolism, intestinal lipid absorption, the yolk lipids and their mobilization, as well as lipids in the nervous system. We also discuss studies in which zebrafish have been employed for the visualization of whole-body lipid distribution and trafficking. Finally, recent advances in using zebrafish as a model for lipid-related diseases, including atherosclerosis, obesity, diabetes and hepatic steatosis are highlighted. As the insights into zebrafish lipid metabolism increase, it is likely that zebrafish as a model organism will become an increasingly powerful tool in lipid research.

model organism

apolipoprotein-e

developmental expression

lipid

gene family

danio-rerio

alcohol exposure

cholesterol

zebrafish

food-deprivation

cholesterol

imaging

vertebrate

fish

triglyceride transfer protein

lipidosis

Författare

M. Holtta-Vuori

Institute of Biomedicine Helsinki

V. T. V. Salo

Institute of Biomedicine Helsinki

Lena Nyberg

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Christian Brackmann

Chalmers, Kemi- och bioteknik, Molekylär mikroskopi

Annika Enejder

Chalmers, Kemi- och bioteknik, Molekylär mikroskopi

P. Panula

Institute of Biomedicine Helsinki

E. Ikonen

Institute of Biomedicine Helsinki

Biochemical Journal

0264-6021 (ISSN) 1470-8728 (eISSN)

Vol. 429 2 235-242

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1042/BJ20100293

PubMed

20578994