Adsorption of proteins on a lipid bilayer
Artikel i vetenskaplig tidskrift, 2010

In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid-lipid pair is 16-25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption.

Adsorption energy

qcm-d

binding

solid-surfaces

monte-carlo simulations

Lipids

membranes

marcks-related

afm

Proteins

Electrostatic interactions

atomic-force microscopy

Poisson-Boltzmann equation

protein

charged macromolecules

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

Bengt Herbert Kasemo

Chalmers, Teknisk fysik, Kemisk fysik

European Biophysics Journal

0175-7571 (ISSN) 1432-1017 (eISSN)

Vol. 39 1477-1482

Ämneskategorier

Fysik

DOI

10.1007/s00249-010-0604-0