Synthesis, Crystal Structure, Quantum Chemical Calculations, DNA Interactions, and Antimicrobial Activity of [Ag(2-amino-3-methylpyridine)2]NO3 and [Ag(pyridine-2-carboxaldoxime)NO3]
Artikel i vetenskaplig tidskrift, 2010

[Ag(2-amino-3-methylpyridine)2]NO3 (1) and [Ag(pyridine-2-carboxaldoxime)NO3] (2) were prepared from corresponding ligands and AgNO3 in water/ethanol solutions, and the products were characterized by IR, elemental analysis, NMR, and TGA. The X-ray crystal structures of the two compounds show that the geometry around the silver(I) ion is bent for complex 1 with nitrate as an anion and trigonal planar for complex 2 with nitrate coordinated. ESI-MS results of solutions of 2 indicate the independent existence in solution of the [Ag(pyridine-2-carboxaldoxime)]+ ion. The geometries of the complexes are well described by DFT calculations using the ZORA relativistic approach. The compounds were tested against 14 different clinically isolated and four ATCC standard bacteria and yeasts and also compared with 17 commonly used antibiotics. Both 1 and 2 exhibited considerable activity against S. lutea, M. lutea, and S. aureus and against the yeast Candida albicans, while 2-amino-3-methylpyridine is slightly active and pyridine-2-carboxaldoxime shows no antimicrobial activity. In addition, the interaction of these metal complexes with DNA was investigated. Both 1 and 2 bind to DNA and reduce its electrophoretic mobility with different patterns of migration, while the ligands themselves induce no change.

antimicrobial activity

Silver(I)

Författare

Morsy A. M. Abu-Youssef

Alexandria University

S.M. Soliman

Alexandria University

Vratislav Langer

Chalmers, Kemi- och bioteknik, Oorganisk miljökemi

Yousry M. Gohar

Alexandria University

Ahmed A. Hasanen

Alexandria University

Mohamed Makhyoun

Alexandria University

Amira H. Zaky

Alexandria University

Lars Öhrström

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Inorganic Chemistry

0020-1669 (ISSN) 1520-510X (eISSN)

Vol. 49 21 9788-9797

Ämneskategorier

Oorganisk kemi

Strukturbiologi

Läkemedelskemi

Teoretisk kemi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1021/ic100581k

Mer information

Skapat

2017-10-08