Dissolution Rate Enhancement of Parabens in PEG Solid Dispersions and Its Influence on the Release from Hydrophilic Matrix Tablets
Artikel i vetenskaplig tidskrift, 2011
The dissolution rate of a homologous series of parabens and their dispersions in
PEG 4x103 was examined. In light of these measurements, the release behavior of the
substances from extended release hydrophilic matrix tablets based on PEO 5x106 was studied.
Tablet release was examined for matrices comprising either a physical mixture of PEG, paraben,
and PEO, or a solid solution of each paraben in PEG, incorporated in the PEO matrix.
Considerable increase of the dissolution rate for the eutectic and in particular solid solution
form of the parabens was observed. The hydration rate of all matrices, as well as polymer release,
was the same. The release rate of methyl, ethyl, and butyl parabens in solid solution form was
similar to that of their crystalline form. However, the release rate of the solid solution form of
propyl paraben was higher than that of its crystalline form, especially in the initial part of the
release. The results indicate that all parabens crystallized in the gel layer of the solid solution
formulations upon the process of tablet dissolution. This was proposed to be an effect of
differences in the dissolution and crystallization kinetics of the parabens.