Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide
Artikel i vetenskaplig tidskrift, 2010

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.

rna

emulsions

interference

microspheres

in-vivo

mechanism

sirna

delivery

Författare

J. Ge

Stanford University

G. B. Jacobson

Stanford University

Tatsiana Lobovkina

Stanford University

Krister Holmberg

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

R. N. Zare

Stanford University

Chemical Communications

1359-7345 (ISSN)

Vol. 46 47 9034-9036

Ämneskategorier

Kemi

DOI

10.1039/c0cc04258g

Mer information

Senast uppdaterat

2018-03-06