Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide
Artikel i vetenskaplig tidskrift, 2010
A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.
rna
emulsions
interference
microspheres
in-vivo
mechanism
sirna
delivery
Författare
J. Ge
Stanford University
G. B. Jacobson
Stanford University
Tatsiana Lobovkina
Stanford University
Krister Holmberg
Chalmers, Kemi- och bioteknik, Teknisk ytkemi
R. N. Zare
Stanford University
Chemical Communications
1359-7345 (ISSN) 1364-548X (eISSN)
Vol. 46 47 9034-9036Ämneskategorier
Kemi
DOI
10.1039/c0cc04258g