Postnatal deficiency of essential fatty acids in mice results in resistance to diet-induced obesity and low plasma insulin during adulthood
Artikel i vetenskaplig tidskrift, 2011

Our objective was to investigate the long-term metabolic effects of postnatal essential fatty acid deficiency (EFAD). Mouse dams were fed an EFAD diet or an isoenergetic control diet 4 days before delivery and throughout lactation. The pups were weaned to standard diet (STD) and were later subdivided into two groups: receiving high fat diet (HFD) or STD. Body composition, energy expenditure, food intake and leptin levels were analyzed in adult offspring. Blood glucose and plasma insulin concentrations were measured before and during a glucose tolerance test. EFAD offspring fed STD were leaner with lower plasma leptin and insulin concentrations compared to controls. EFAD offspring fed HFD were resistant to diet-induced obesity, had higher energy expenditure and lower levels of plasma leptin and insulin compared to controls. These results indicate that the fatty acid composition during lactation is important for body composition and glucose tolerance in the adult offspring.

Diet-induced obesity

Essential fatty acids

Body composition

Leptin

Insulin-like growth factor I

Maternal diet

Insulin

Energy expenditure

Författare

Vilborg Palsdottir

Göteborgs universitet

Anna Wickman

Göteborgs universitet

Niklas Andersson

Göteborgs universitet

Rahil Hezaveh

Göteborgs universitet

Bob Olsson

Göteborgs universitet

Britt Gabrielsson

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Livsmedelsvetenskap

Birgitta Strandvik

Göteborgs universitet

Prostaglandins, Leukotrienes and Essential Fatty Acids

1532-2823 (ISSN)

Vol. 84 3-4 85-92

Ämneskategorier

Medicinsk biovetenskap

Biokemi och molekylärbiologi

Utvecklingsbiologi

Biomedicinsk laboratorievetenskap/teknologi

Övrig annan samhällsvetenskap

Näringslära

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1016/j.plefa.2010.11.002

PubMed

21177089