The consequence of the chemical composition of HPMC in matrix tablets on the release behaviour of model drug substances having different solubility
Artikel i vetenskaplig tidskrift, 2011

This study investigates the effect of the chemical heterogeneity of hydroxypropyl methylcellulose (HPMC) on the release of model drug substances from hydrophilic matrix tablets. The hypothesis was that the release of drug substances could be influenced by possible interactions with HPMC batches having different chemical heterogeneity. The cloud point of the most heterogeneous batch was more affected by the model drug substances, methylparaben and butylparaben, and most by butylparaben with the lowest solubility. The different clouding behaviour was explained by the heterogeneously substituted batches being more associative and the more lipophilic butylparaben being able to interact more efficiently with the hydrophobic HPMC transient crosslinks that formed. Interestingly, tablet compositions of the heterogeneously substituted HPMC batches released the more soluble methylparaben at lower rates than butylparaben. The explanation is that the hydrophobic HPMC interactions with butylparaben made the gel of the tablet less hydrated and more fragile and therefore more affected by erosional stresses. In contrast, drug release from compositions consisting of the more homogeneously substituted batches was affected to a minor extent by the drugs and was very robust within the experimental variations. The present study thus reveals that there can be variability in drug release depending on the lipophilicity of the drug and the substituent heterogeneity of the HPMC used.

hydroxypropylmethylcellulose

substitution pattern

HPMC

Hydrophilic matrix tablets

cellulose

temperature

Polymer erosion

delivery systems

polymer

dissolution behavior

hydroxypropyl methylcellulose

disintegration

Chemical heterogeneous

Solubility

Drug release

particle-size

Författare

Anna Viridén

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

SuMo Biomaterials

Bengt Wittgren

AstraZeneca AB

Anette Larsson

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

European Journal of Pharmaceutics and Biopharmaceutics

0939-6411 (ISSN)

Vol. 77 1 99-110

Ämneskategorier

Kemi

DOI

10.1016/j.ejpb.2010.11.004

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Senast uppdaterat

2018-03-21