Are the complex distributed genetic networks inherently oscillatory and chaotic?
Artikel i vetenskaplig tidskrift, 2011

Complex mRNA-protein networks with distributed regulation of gene transcription are often mimicked by random Boolean networks. According to this mapping, the gene-expression kinetics are expected to depend strongly on the network connectivity, m. Specifically, the kinetics are predicted to be oscillatory or chaotic for m > 2. We analyze this problem in more detail by using an accurate model explicitly describing the mRNA-protein interplay with randomly organized transcriptional regulation. Contrary to the expectations, our mean-field calculations and Monte Carlo simulations performed for m = 1, 2 and 4 show that oscillations and chaos are lacking irrespective of m.

expression

models

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

JETP Letters

0021-3640 (ISSN) 1090-6487 (eISSN)

Vol. 93 41-45

Ämneskategorier

Fysik

DOI

10.1134/s0021364011010097