Robust servo control of a novel type 1 diabetic model
Artikel i vetenskaplig tidskrift, 2011

Robust servo control of a model-based biomedical application is presented in the article. The glucose-insulin control of type 1 diabetic patients is considered to be solved using the results of post-modern robust control principles. The paper uses a recently published glucose-insulin model and presents the transformation of the model to describe the dynamics of type 1 diabetes mellitus. The nonlinear plant is then linearized at a given steady state point. In order to characterize the uncertainty around the nominal model in frequency domain, a parametric nonlinear model sensitivity analysis is performed using gridding method. The aim of the paper is to underline the viability of the robust servo, linear mu-control algorithm tested in highly nonlinear closed-loop simulation environment. Using two degree-of-freedom robust controller, the structured singular value of the closed-loop is designed to fulfill the robust performance requirements and assure glucose level control. Glucose level tracking is ensured under simulated and realistic exogenous meal disturbances.

glucose tracking

blood-glucose control


type 1 diabetes

insulin sensitivity


control design




robust control



intravenous glucose



L. Kovacs

Budapesti Muszaki es Gazdasagtudomanyi Egyetem

Balázs Adam Kulcsár

Chalmers, Signaler och system, System- och reglerteknik, Reglerteknik

A. Gyorgy

Budapesti Muszaki es Gazdasagtudomanyi Egyetem

Z. Benyo

Budapesti Muszaki es Gazdasagtudomanyi Egyetem

Optimal Control Applications and Methods

0143-2087 (ISSN) 1099-1514 (eISSN)

Vol. 32 2 215-238


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