Effect of annealing time and addition of lactose on release of a model substance from Eudragit® RS coated pellets produced by a fluidized bed coater
Artikel i vetenskaplig tidskrift, 2011

The aim of this study was to investigate the effects of annealing time and addition of lactose in coating liquid formulations on the release of a model substance, methylene blue (MB), from pellets coated with Eudragit (R) RS 30 D. The microcrystalline cellulose pellets were layered with MB before coating with aqueous dispersions of Eudragit (R) RS 30 D using a Wurster-type fluidized bed coater. The coating processes and conditions were validated and optimized before the final coating. The uncoated and coated pellets were characterized for their size, MB content, morphology and MB release. The results demonstrated that a stable coating process can be developed to produce repeatable batches of pellets. The film thickness was calculated and found to be similar to those observed from scanning electron microscope. The increased annealing time led to a more coherent film. The drug release was found to vary depending on the duration of annealing time and the addition of lactose. Addition of lactose gave a faster MB release and without any initial lag period in the release profile whereas the increased annealing time slowed down the MB release and increased the lag period.

systems

latex film formation

formulation

dispersions

acid

Fluidized bed coating

delivery

Film coating

drug-release

Pellets

Eudragit (R) RS 30 D

Lactose

ethylcellulose

Annealing

Författare

Ulrich Heckötter

Chalmers, Kemi- och bioteknik

Anette Larsson

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

SuMo Biomaterials

P. Sriamornsak

Silpakorn University

Fachhochschule fur Technik und Wirtschaft Berlin

M. Kumpugdee-Vollrath

Fachhochschule fur Technik und Wirtschaft Berlin

Chemical Engineering Research and Design

0263-8762 (ISSN) 1744-3563 (eISSN)

Vol. 89 697-705

Ämneskategorier

Kemiteknik

DOI

10.1016/j.cherd.2010.09.016