Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication
Artikel i vetenskaplig tidskrift, 2011

The magnetisable stent assisted magnetic targeted drug delivery system in a physiologically stretched vessel is considered theoretically. The changes in the mechanical behaviour of the vessel are analysed under the influence of mechanical forces generated by blood pressure. In this 2D mathematical model a ferromagnetic, coiled wire stent is implanted to aid collection of magnetic drug carrier particles in an elastic tube, which has similar mechanical properties to the blood vessel. A cyclic mechanical force is applied to the elastic tube to mimic the mechanical stress and strain of both the stent and vessel while in the body due to pulsatile blood circulation. The magnetic dipole–dipole and hydrodynamic interactions for multiple particles are included and agglomeration of particles is also modelled. The resulting collection efficiency of the mathematical model shows that the system performance can decrease by as much as 10% due to the effects of the pulsatile blood circulation.

Simulation

Hydrodynamic interaction

Magnetizable stent

Dipole–dipole interaction

Magnetic nanoparticle

Stretch vessel

Magnetic drug targeting

Författare

Adil Mardinoglu

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Journal of Magnetism and Magnetic Materials

0304-8853 (ISSN)

Vol. 323 324-329

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi

DOI

10.1016/j.jmmm.2010.09.028