Many particle magnetic dipole–dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting
Artikel i vetenskaplig tidskrift, 2010

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter is considered both experimentally (in vitro) and theoretically. The results of a 2D mathematical model are compared with 3D experimental results for a magnetizable wire stent. In this experiment a ferromagnetic, coiled wire stent is implanted to aid collection of particles which consist of single domain magnetic nanoparticles (radius ). In order to model the agglomeration of particles known to occur in this system, the magnetic dipole–dipole and hydrodynamic interactions for multiple particles are included. Simulations based on this mathematical model were performed using open source C++ code. Different initial positions are considered and the system performance is assessed in terms of collection efficiency. The results of this model show closer agreement with the measured in vitro experimental results and with the literature. The implications in nanotechnology and nanomedicine are based on the prediction of the particle efficiency, in conjunction with the magnetizable stent, for targeted drug delivery.

Simulation

High gradient magnetic separation (HGMS)

Magnetizable stent

Dipole–dipole interaction

Hydrodynamic interaction

Magnetic nanoparticle

Magnetic drug targeting

Författare

Adil Mardinoglu

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

Journal of Magnetism and Magnetic Materials

0304-8853 (ISSN)

Vol. 322 15 2087-2094

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Bioinformatik och systembiologi