Design of a wideband multi-channel system for time reversal hyperthermia
Artikel i vetenskaplig tidskrift, 2012

Purpose: To design and test a wideband multi-channel amplifier system for time reversal (TR) microwave hyperthermia, operating in the frequency range 300 MHz-1 GHz, enabling operation in both pulsed and continuous wave regimes. This is to experimentally verify that adaptation of the heating pattern with respect to tumour size can be realised by varying the operating frequency of the antennas and potentially by using Ultra-wideband (UWB) pulse sequences instead of pure harmonic signals. Materials and methods: The proposed system consists of 12 identical channels driven by a common reference signal. The power and phase settings are applied with resolutions of 0.1W and 0.1 degrees, respectively. Using a calibration procedure, the measured output characteristics of each channel are interpolated using polynomial functions, which are then implemented into a system software algorithm driving the system feedback loop. Results: The maximum output power capability of the system varies with frequency, between 90 and 135W with a relative power error of +/- 6%. A phase error in the order of +/- 4 degrees has been achieved within the entire frequency band. Conclusions: The developed amplifier system prototype is capable of accurate power and phase delivery, over the entire frequency band of the system. The output power of the present system allows for an experimental verification of a recently developed TR-method on phantoms or animals. The system is suitable for further development for head and neck tumours, breast or extremity applications.

soft-tissue sarcomas

randomized-trial

applicator

time reversal

hyperthermia

neck

microwave hyperthermia

regional

plus hyperthermia

amplifier system

amplifier system

feedback control

electromagnetic phased-arrays

hyperthermia

annular phased array

breast-cancer

Författare

Hana Dobsicek Trefna

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

P. Togni

Ceske vysoke uceni technicke v Praze

Reza Shiee

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

J. Vrba

Ceske vysoke uceni technicke v Praze

Mikael Persson

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

International Journal of Hyperthermia

0265-6736 (ISSN) 1464-5157 (eISSN)

Vol. 28 175-183

Ämneskategorier

Elektroteknik och elektronik

DOI

10.3109/02656736.2011.641655