A generic 3D kinetic model of gene expression
Artikel i vetenskaplig tidskrift, 2012

Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.

diffusion

translation

mRNA

mRNA and protein diffusion and degradation

subcellular-localization

transcription

bacterial-cells

gene transcription

subcellular processes

messenger-rna

mRNA synthesis

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

Central European Journal of Physics

1895-1082 (ISSN) 1644-3608 (eISSN)

Vol. 10 2 533-537

Ämneskategorier

Fysik

DOI

10.2478/s11534-012-0011-5

Mer information

Senast uppdaterat

2021-02-18