A generic 3D kinetic model of gene expression
Artikel i vetenskaplig tidskrift, 2012
Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.
mRNA and protein diffusion and degradation
mRNA
mRNA synthesis
transcription
messenger-rna
translation
diffusion
subcellular-localization
gene transcription
bacterial-cells
subcellular processes
Författare
Vladimir Zhdanov
Chalmers, Teknisk fysik, Kemisk fysik
Central European Journal of Physics
1895-1082 (ISSN) 1644-3608 (eISSN)
Vol. 10 2 533-537Ämneskategorier
Fysik
DOI
10.2478/s11534-012-0011-5