A generic 3D kinetic model of gene expression
Artikel i övriga tidskrifter, 2012

Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.

transcription

messenger-rna

gene transcription

mRNA

translation

mRNA synthesis

diffusion

subcellular processes

subcellular-localization

mRNA and protein diffusion and degradation

bacterial-cells

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

Central European Journal of Physics

1895-1082 (ISSN) 1644-3608 (eISSN)

Vol. 10 2 533-537

Ämneskategorier

Fysik

DOI

10.2478/s11534-012-0011-5