Fungal fludioxonil sensitivity is diminished by a constitutively active form of the group III histidine kinase
Artikel i vetenskaplig tidskrift, 2012

The fungicide fludioxonil is used to control plant-pathogenic fungi by causing improper activation of the Hog1-type MAPK. However, the appearance of fludioxonil resistant mutants, mostly caused by mutations in the group III histidine kinases, poses a serious problem. Moreover, such mutations cause also hyperosmotic sensitivity and the underlying mechanism has been elusive for a long time. Using Saccharomyces cerevisiae as an experimental host, we show that those phenotypes are conferred by a constitutively active form of the group III histidine kinase. Our results explain the different reasons for fludioxonil resistance conferred by its deletion and missense mutation.

Histidine kinase

Fludioxonil

Two-component system

HOG pathway

Författare

Kentaro Furukawa

Göteborgs universitet

Anmoldeep Randhawa

Harsimran Kaur

Alok Mondal

Stefan Hohmann

Göteborgs universitet

FEBS Letters

0014-5793 (ISSN)

Vol. 586 16 2417-2422

Ämneskategorier

Genetik

DOI

10.1016/j.febslet.2012.05.057