Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men.
Artikel i vetenskaplig tidskrift, 2013

Context:Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity treatment.Objective:The objective of the study was a search for sex differences in adipose tissue function.Design and Setting:This was an exploratory study performed at a university hospital.Participants and Main Outcome Measures:Resting metabolic rate (RMR), body composition, and sc adipose tissue genome-wide expression were measured in the SOS Sib Pair study (n = 732).Results:The relative contribution of fat mass to RMR and the metabolic rate per kilogram adipose tissue was higher in women than in men (P value for sex by fat mass interaction = .0019). Women had increased expression of genes involved in mitochondrial function, here referred to as a mitochondrial gene signature. Analysis of liver, muscle, and blood showed that the pronounced mitochondrial gene signature in women was specific for adipose tissue. Brown adipocytes are dense in mitochondria, and the expression of the brown adipocyte marker uncoupling protein 1 was 5-fold higher in women compared with men in the SOS Sib Pair Study (P = 7.43 × 10(-7)), and this was confirmed in a cross-sectional, population-based study (n = 83, 6-fold higher in women, P = .00256).Conclusions:The increased expression of the brown adipocyte marker uncoupling protein 1 in women indicates that the higher relative contribution of the fat mass to RMR in women is in part explained by an increased number of brown adipocytes.

Författare

[Person a6d41f11-8d7d-4e62-9c67-31866db6eaad not found]

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

[Person ea75d34c-bfa2-4eba-b868-8dc6a36ed01b not found]

Göteborgs universitet

[Person d5138398-25e5-48f7-8189-934dab384499 not found]

Göteborgs universitet

[Person b3194b1a-bc01-4993-aef1-468d45e6f739 not found]

Göteborgs universitet

[Person f4cfb92d-6047-42d7-baaa-69e8d9446520 not found]

Göteborgs universitet

[Person 23c437c3-e93b-42c6-a660-453a028ab6c3 not found]

Göteborgs universitet

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Göteborgs universitet

[Person ab7ead77-5831-4760-a90f-09353fdfbab8 not found]

Göteborgs universitet

[Person a78e7742-554d-48de-851a-e88aface5c11 not found]

Centre national de la recherche scientifique (CNRS)

Hammersmith Hospital

[Person 47178703-cf20-4a30-ae9c-6eecc5f4f83c not found]

Hammersmith Hospital

[Person 30a8e961-dab2-4813-ad39-14e13c34ac44 not found]

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Systembiologi

[Person 53e507a6-dcd1-4334-8caf-21fa884aeaf3 not found]

Göteborgs universitet

The Journal of clinical endocrinology and metabolism

1945-7197 (eISSN)

Vol. 98 2 E370-E378

Ämneskategorier

Klinisk medicin

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

DOI

10.1210/jc.2012-2764

PubMed

23264395

Mer information

Senast uppdaterat

2018-09-07