Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties
Artikel i vetenskaplig tidskrift, 2012

Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

dogs

dental implants

modulus

mechanical-properties

biomechanics

tissue

osseointegration

histology

calcium phosphate

topography

nanostructures

surfaces

mineral-content

titanium

Författare

Ryo Jimbo

Malmö universitet

Paulo G Coelho

New York University

M. S. Bryington

Ohio State University

M. Baldassarri

New York University

N. Tovar

New York University

F Currie

Promimic AB

Mariko Hayashi

Malmö universitet

M. N. Janal

New York University

Martin Andersson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Daisuke Ono

Nagasaki University

Stefan Vandeweghe

Malmö universitet

Universiteit Gent

Ann Wennerberg

Malmö universitet

Journal of Dental Research

0022-0345 (ISSN)

Vol. 91 1172-1177

Ämneskategorier

Odontologi

DOI

10.1177/0022034512463240