Regulatory Effects of Cu, Zn, and Ca on Fe Absorption: The Intricate Play between Nutrient Transporters
Artikel i vetenskaplig tidskrift, 2013

Iron is an essential nutrient for almost every living organism because it is required in a number of biological processes that serve to maintain life. In humans, recycling of senescent erythrocytes provides most of the daily requirement of iron. In addition, we need to absorb another 1-2 mg Fe from the diet each day to compensate for losses due to epithelial sloughing, perspiration, and bleeding. Iron absorption in the intestine is mainly regulated on the enterocyte level by effectors in the diet and systemic regulators accessing the enterocyte through the basal lamina. Recently, a complex meshwork of interactions between several trace metals and regulatory proteins was revealed. This review focuses on advances in our understanding of Cu, Zn, and Ca in the regulation of iron absorption. Ascorbate as an important player is also considered.

nramp2 expression

transcription

Ca

intestinal epithelial-cells

iron

copper transporter

Cu

Zn

duodenal cytochrome-b

Fe

fpn1

dietary iron

ascorbic-acid

absorption

hepcidin expression

ascorbate

iron-absorption

caco-2 cells

Författare

Nathalie Scheers

Chalmers, Kemi- och bioteknik, Livsvetenskaper, Livsmedelsvetenskap

Nutrients

2072-6643 (ISSN)

Vol. 5 3 957-970

Ämneskategorier

Biologiska vetenskaper

Näringslära

Styrkeområden

Livsvetenskaper och teknik

DOI

10.3390/nu5030957

Mer information

Skapat

2017-10-08