Regulatory Effects of Cu, Zn, and Ca on Fe Absorption: The Intricate Play between Nutrient Transporters
Reviewartikel, 2013
Iron is an essential nutrient for almost every living organism because it is required in a number of biological processes that serve to maintain life. In humans, recycling of senescent erythrocytes provides most of the daily requirement of iron. In addition, we need to absorb another 1-2 mg Fe from the diet each day to compensate for losses due to epithelial sloughing, perspiration, and bleeding. Iron absorption in the intestine is mainly regulated on the enterocyte level by effectors in the diet and systemic regulators accessing the enterocyte through the basal lamina. Recently, a complex meshwork of interactions between several trace metals and regulatory proteins was revealed. This review focuses on advances in our understanding of Cu, Zn, and Ca in the regulation of iron absorption. Ascorbate as an important player is also considered.
Ca
absorption
ascorbate
hepcidin expression
duodenal cytochrome-b
nramp2 expression
intestinal epithelial-cells
iron-absorption
dietary iron
caco-2 cells
Zn
Fe
transcription
fpn1
ascorbic-acid
iron
Cu
copper transporter
Författare
Nathalie Scheers
Chalmers, Kemi- och bioteknik, Livsvetenskaper
Nutrients
2072-6643 (ISSN) 20726643 (eISSN)
Vol. 5 3 957-970Ämneskategorier
Biologiska vetenskaper
Näringslära
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.3390/nu5030957