Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging
Artikel i vetenskaplig tidskrift, 2013

In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer release profile, possibly due to the sparse amount of usable pure polymer dissolution data. In addition to the case study, a sensitivity analysis of model parameters relevant to drug release was performed. The analysis revealed important information that can be useful in the drug formulation process.

Författare

E. Kaunisto

Lunds universitet

Farhad Tajarobi

AstraZeneca AB

Susanna Abrahmsén-Alami

AstraZeneca AB

Anette Larsson

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

SuMo Biomaterials

B. Nilsson

Lunds universitet

A. Axelsson

Lunds universitet

European Journal of Pharmaceutical Sciences

0928-0987 (ISSN)

Vol. 48 698-708

Ämneskategorier

Farmakologi och toxikologi

DOI

10.1016/j.ejps.2012.12.030