Preparation of Porous Poly(3-Hydroxybutyrate) Films by Water-Droplet Templating
Artikel i vetenskaplig tidskrift, 2012

Porous resorbable implants are of great interest since they may deliver bioactives or drug s, facilitate the transport of body fluids or degradation products and provide a favorable environment for cell attachment and growth. In this work we report on a method using concentrated emulsions to template interconnected solid foam materials and to produce highly porous poly(3-hydroxybutyrate) (PHB) materials. Porous PHB films were cast made from water-in-oil template emulsions including Span 80 and lithium sulphate. The films were characterized by SEM-EDX and DMA. The water uptake of the films was recorded in orde r to determine the fraction water available pores. The results show that the ad- dition of lithium sulphate allows a fine tuning of the film morphology with respect to porosity and interconnected po- rous structure. The film porosity was determined to 51% ± 3%, 52% ± 3% and 45% ± 3% for the films made with 0%, 2.9% and 14.3% lithium sulphate in the template emulsion , respectively. The fraction water available pores was sig- nificantly lower, 11% ±3%, 38% ±12% and 48% ± 7% for films with 0%, 2.9% and 14.3% litium sulphate respectively. Differences in fraction water available pores and total porosity for the films reflects the film morphology and differ- ences in pore interconnection.

Författare

Anna Bergstrand

Chalmers, Kemi- och bioteknik

SuMo Biomaterials

Helene Andersson

Johanna Cramby

Chalmers, Kemi- och bioteknik

Anette Larsson

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

Journal of Biomaterials and Nanobiotechnology

2158-7027 (ISSN)

Vol. 3

Ämneskategorier

Kemiteknik

Annan kemi

Kemi

Styrkeområden

Materialvetenskap

DOI

10.4236/jbnb.2012.34043