Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.
Artikel i vetenskaplig tidskrift, 2001

Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.

Multivariate Analysis

Antineoplastic

Computer-Assisted

blood

Spectrum Analysis

Raman

Principal Component Analysis

chemistry

blood

Signal Processing

chemistry

Doxorubicin

chemistry

Cattle

Plasma

Antibiotics

Animals

Författare

Charlotte Eliasson

Chalmers, Institutionen för kemi och biovetenskap

Anders Lorén

Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi

K V Murty

M Josefson

Mikael Käll

Göteborgs universitet

Jonas Abrahamsson

Göteborgs universitet

Katarina Abrahamsson

Göteborgs universitet

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

1386-1425 (ISSN)

Vol. 57 1907-15

Ämneskategorier

Annan medicinsk grundvetenskap

PubMed

11506043