Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.
Artikel i vetenskaplig tidskrift, 2001
Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.
Multivariate Analysis
Antineoplastic
Computer-Assisted
blood
Spectrum Analysis
Raman
Principal Component Analysis
chemistry
blood
Signal Processing
chemistry
Doxorubicin
chemistry
Cattle
Plasma
Antibiotics
Animals
Författare
Charlotte Eliasson
Chalmers, Institutionen för kemi och biovetenskap
Anders Lorén
Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi
K V Murty
M Josefson
Mikael Käll
Göteborgs universitet
Jonas Abrahamsson
Göteborgs universitet
Katarina Abrahamsson
Göteborgs universitet
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
1386-1425 (ISSN)
Vol. 57 9 1907-15Ämneskategorier (SSIF 2011)
Annan medicinsk grundvetenskap
PubMed
11506043