Promises and challenges of nanoplasmonic devices for refractometric biosensing
Artikel i vetenskaplig tidskrift, 2013

Optical biosensors based on surface plasmon resonance (SPR) in metallic thin films are currently standard tools for measuring molecular binding kinetics and affinities - an important task for biophysical studies and pharmaceutical development. Motivated by recent progress in the design and fabrication of metallic nanostructures, such as nanoparticles or nanoholes of various shapes, researchers have been pursuing a new generation of biosensors harnessing tailored plasmonic effects in these engineered nanostructures. Nanoplasmonic devices, while demanding nanofabrication, offer tunability with respect to sensor dimension and physical properties, thereby enabling novel biological interfacing opportunities and extreme miniaturization. Here we provide an integrated overview of refractometric biosensing with nanoplasmonic devices and highlight some recent examples of nanoplasmonic sensors capable of unique functions that are difficult to accomplish with conventional SPR. For example, since the local field strength and spatial distribution can be readily tuned by varying the shape and arrangement of nanostructures, biomolecular interactions can be controlled to occur in regions of high field strength. This may improve signal-to-noise and also enable sensing a small number of molecules. Furthermore, the nanoscale plasmonic sensor elements may, in combination with nanofabrication and materials-selective surface-modifications, make it possible to merge affinity biosensing with nanofluidic liquid handling.

enzyme-linked biosensing

Optical biosensors

single molecule detection

P869

PHYSICAL REVIEW

figure of merit

nanoparticle

WELL CJ

site-specific chemistry

METAL-FILMS

1959

EXTRAORDINARY OPTICAL-TRANSMISSION

surface plasmon resonance

nanoho

SENSING CHARACTERISTICS

NANOPARTICLES

supported lipid bilayer

REAL-TIME

SILVER

SURFACE-PLASMON RESONANCE

NANOHOLE ARRAYS

GOLD-NANOPARTICLE SENSOR

plasmonics

refractometric sensors

SUBWAVELENGTH HOLE ARRAYS

V115

COLLOIDAL GOLD

pore-spanning lipid membrane

Författare

Andreas Dahlin

Chalmers, Teknisk fysik, Bionanofotonik

N. J. Wittenberg

University of Minnesota System

Fredrik Höök

Chalmers, Teknisk fysik, Biologisk fysik

S. H. Oh

University of Minnesota System

Seoul National University

Nanophotonics

2192-8606 (eISSN)

Vol. 2 2 83-101

Ämneskategorier

Materialteknik

Atom- och molekylfysik och optik

Nanoteknik

DOI

10.1515/nanoph-2012-0026