Promises and challenges of nanoplasmonic devices for refractometric biosensing
Journal article, 2013
Optical biosensors based on surface plasmon resonance (SPR) in metallic thin films are currently standard tools for measuring molecular binding kinetics and affinities - an important task for biophysical studies and pharmaceutical development. Motivated by recent progress in the design and fabrication of metallic nanostructures, such as nanoparticles or nanoholes of various shapes, researchers have been pursuing a new generation of biosensors harnessing tailored plasmonic effects in these engineered nanostructures. Nanoplasmonic devices, while demanding nanofabrication, offer tunability with respect to sensor dimension and physical properties, thereby enabling novel biological interfacing opportunities and extreme miniaturization. Here we provide an integrated overview of refractometric biosensing with nanoplasmonic devices and highlight some recent examples of nanoplasmonic sensors capable of unique functions that are difficult to accomplish with conventional SPR. For example, since the local field strength and spatial distribution can be readily tuned by varying the shape and arrangement of nanostructures, biomolecular interactions can be controlled to occur in regions of high field strength. This may improve signal-to-noise and also enable sensing a small number of molecules. Furthermore, the nanoscale plasmonic sensor elements may, in combination with nanofabrication and materials-selective surface-modifications, make it possible to merge affinity biosensing with nanofluidic liquid handling.
nanoparticle
Optical biosensors
NANOPARTICLES
single molecule detection
pore-spanning lipid membrane
refractometric sensors
NANOHOLE ARRAYS
SUBWAVELENGTH HOLE ARRAYS
site-specific chemistry
EXTRAORDINARY OPTICAL-TRANSMISSION
SENSING CHARACTERISTICS
supported lipid bilayer
enzyme-linked biosensing
nanoho
METAL-FILMS
GOLD-NANOPARTICLE SENSOR
COLLOIDAL GOLD
WELL CJ
surface plasmon resonance
SURFACE-PLASMON RESONANCE
1959
PHYSICAL REVIEW
plasmonics
figure of merit
REAL-TIME
V115
P869
SILVER
Author
Andreas Dahlin
Chalmers, Applied Physics, Bionanophotonics
N. J. Wittenberg
University of Minnesota
Fredrik Höök
Chalmers, Applied Physics, Biological Physics
S. H. Oh
Seoul National University
University of Minnesota
Nanophotonics
21928614 (eISSN)
Vol. 2 2 83-101Subject Categories
Materials Engineering
Atom and Molecular Physics and Optics
Nano Technology
DOI
10.1515/nanoph-2012-0026