Andreas Dahlin

Professor at Applied Chemistry

I work with functional nanostructures: In my group we fabricate new structures and functionalize them chemically in order to evaluate them for various applications. Our work is strongly interdisciplinary and we aim to develop new bioanalytical devices or synthetic biological systems on the nanoscale. We are also addressing fundamental scientific questions, for instance within supramolecular chemistry and polymer physics. Read more about ongoing research project below.

Molecular Trapping

A lot of my work relates to nanopores in one way or another. To put it simple, I work with very small holes. I am far from the only one in the world working with nanopores, but my nanopores are quite different from those typically produced by other research groups. In particular, I use metallic layers to give the structures plasmonic resonances and I chemically modify my nanopores with polymers.

We are all used to having doors and rooms to locate people. I am interested in achieving the same thing but with molecules instead of people and on the nanoscale. This work is partly inspired by the highly specific nanoscale gates (doors) found in nature, such as the nuclear pore complex which controls what molecules are allowed to enter the nuclei of eucaryotic cells (where the DNA is stored). I am interested in making nanoscale gates that can be opened and closed by electric signals. This can be accomplished by using special polymers that undergo shape changes in response to changes in temperature or the chemical environment. Also, we try to make apertures that are "not quite" possible for the molecules to pass through spontaneously, so that we can use electrokinetic forces to squeeze them through on demand.

The dream scenario is to have a platform where one can trap biological molecules such as proteins

- at physiological conditions

- without tethering to a surface

- for long-term observations (at least minutes)

- with exact control of how many molecules that are confined

Especially the last point is currently not possible with any technology. The trapping platform would enable new possibilities in studies of intrinsically disordered proteins, protein aggregation and protein interactions. Our first publication on this topic recently came out:

Stable trapping of multiple proteins at physiological conditions using nanoscale chambers with macromolecular gates.

Biopharmaceutical Purification

In this recently started project, we try to use polymer brushes for protein purification. The idea is based on our recent insights regarding how polymers interact with proteins and how this can be controlled by electrochemical potentials. We have recently filed a patent and launched a startup company which tries to commercialize the technology:

Nyctea Technologies

We are currently looking for funding to continue with more academic research on this topic, not only utilization of our findings so far.

Nuclear Pore Mimics

In the nuclear envelope surrounding the nucleus of eucaryotic cells, there exists a nanoscale machinery which selectively transports biomolecules in or out of the nucleus. The most remarkable thing about the barrier (in my opinion) is that the "cargo"molecules are transported via "shuttles" that move freely through the barrier. Even though the shuttle-cargo complex is larger than the cargo alone, it can pass the barrier, while the cargo cannot.

This project is mostly about fundamental science, aiming to obtain a better understanding of disordered macromolecules and their interactions. We have written a review paper on the topic:

Pore performance: artificial nanoscale constructs that mimic the biomolecular transport of the nuclear pore complex.

Source: chalmers.se
Image of Andreas Dahlin

Showing 74 publications

2024

Electrochromic Passive Matrix Display Utilizing Diode-Like Redox Reactions on Indium-Tin-Oxide

Oliver Olsson, Marika Gugole, Jolie Blake et al
Advanced Engineering Materials. Vol. 26 (8)
Journal article
2023

Enhanced electrochromic switching contrast in the blue by 3,4-propylenedioxypyrrole - Implementation on structural colors

Oliver Olsson, Marika Gugole, Andreas Dahlin
Nanophotonics. Vol. 12 (8), p. 1591-1599
Journal article
2023

All-Printed Multilayers and Blends of Poly(dioxythiophene) Derivatives Patterned into Flexible Electrochromic Displays

Robert Brooke, Ioannis Petsagkourakis, Subimal Majee et al
Macromolecular Materials and Engineering. Vol. 308 (2)
Journal article
2023

Video-Rate Switching of High-Reflectivity Hybrid Cavities Spanning All Primary Colors

Kunli Xiong, Oliver Olsson, Stefano Rossi et al
Advanced Materials. Vol. 35 (31)
Journal article
2023

Trapping Proteins in Nanoscale Chambers

Jesper Medin, Justas Svirelis, Andreas Dahlin
European Biophysics Journal. Vol. 52 (SUPPL 1), p. S94-S94
Other text in scientific journal
2023

Stable trapping of multiple proteins at physiological conditions using nanoscale chambers with macromolecular gates

Justas Svirelis, Zeynep Adali, Gustav Emilsson et al
Nature Communications. Vol. 14 (1)
Journal article
2023

The role of membrane complexity in the early entry stages of SARS-CoV-2 variants

Dario Valter Conca, Fouzia Bano, Julius von Wiren et al
European Biophysics Journal. Vol. 52 (SUPPL 1), p. S176-S176
Other conference contribution
2023

Comparison of Electrodeposited and Sputtered Tungsten Trioxide Films for Inorganic Electrochromic Nanostructures

Marika Gugole, Oliver Olsson, Vandna Kumari Gupta et al
ACS Applied Optical Materials. Vol. 1 (2), p. 558-568
Journal article
2023

Chemically functionalised nanopores for protein trapping

Julia Järlebark, John Andersson, Andreas Dahlin
European Biophysics Journal. Vol. 52 (SUPPL 1), p. S187-S187
Other text in scientific journal
2023

Polymer Brushes on Silica Nanostructures Prepared by Aminopropylsilatrane Click Chemistry: Superior Antifouling and Biofunctionality

John Andersson, Julia Järlebark, Sriram Kesarimangalam et al
ACS Applied Materials & Interfaces. Vol. 15 (7), p. 10228-10239
Journal article
2022

Scalable Reflective Plasmonic Structural Colors from Nanoparticles and Cavity Resonances – the Cyan-Magenta-Yellow Approach

Jolie Blake, Stefano Rossi, Martin Jonsson et al
Advanced Optical Materials. Vol. 10 (13)
Journal article
2022

Surface plasmon resonance sensing with thin films of palladium and platinum - quantitative and real-time analysis

John Andersson, Justas Svirelis, Gustav Ferrand-Drake Del Castillo et al
Physical Chemistry Chemical Physics. Vol. 24 (7), p. 4588-4594
Journal article
2022

Pore performance: artificial nanoscale constructs that mimic the biomolecular transport of the nuclear pore complex

John Andersson, Justas Svirelis, Jesper Medin et al
Nanoscale Advances. Vol. 4 (23), p. 4925-4937
Review article
2022

Electrically Switchable Polymer Brushes for Protein Capture and Release in Biological Environments**

Gustav Ferrand-Drake Del Castillo, Maria Kyriakidou, Zeynep Adali et al
Angewandte Chemie - International Edition. Vol. 61 (22)
Journal article
2022

Accurate Correction of the "bulk Response" in Surface Plasmon Resonance Sensing Provides New Insights on Interactions Involving Lysozyme and Poly(ethylene glycol)

Justas Svirelis, John Andersson, Anna Stradner et al
ACS Sensors. Vol. 7 (4), p. 1175-1182
Journal article
2021

Biochemical Sensing with Nanoplasmonic Architectures: We Know How but Do We Know Why?

Andreas Dahlin
Annual Review of Analytical Chemistry. Vol. 14, p. 281-297
Review article
2021

A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex

Alessio Fragasso, Hendrik W. de Vries, John Andersson et al
Nature Communications. Vol. 12 (1), p. 2010-
Journal article
2021

De Novo Computational Design of Disordered Fg-Nucleoporins

Henry de Vries, Alessio Fragasso, Tegan Otto et al
Other conference contribution
2021

Control of Polymer Brush Morphology, Rheology, and Protein Repulsion by Hydrogen Bond Complexation

John Andersson, Gustav Ferrand-Drake Del Castillo, Pierluigi Bilotto et al
Langmuir. Vol. 37 (16), p. 4943-4952
Journal article
2021

Tuning the Thermoresponsive Behavior of Surface-Attached PNIPAM Networks: Varying the Crosslinker Content in SI-ATRP

Sophia Thiele, John Andersson, Andreas Dahlin et al
Langmuir. Vol. 37 (11), p. 3391-3398
Journal article
2021

Evaluation of the Forsvall biopsy needle in an ex vivo model of transrectal prostate biopsy - a novel needle design with the objective to reduce the risk of post-biopsy infection

Andreas Forsvall, Jane Fisher, Jose Francisco Pereira Cardoso et al
Scandinavian Journal of Urology. Vol. 55 (3), p. 227-234
Journal article
2021

Video Speed Switching of Plasmonic Structural Colors with High Contrast and Superior Lifetime

Kunli Xiong, Oliver Olsson, Justas Svirelis et al
Advanced Materials. Vol. 33 (41)
Journal article
2021

Electrochromic Inorganic Nanostructures with High Chromaticity and Superior Brightness

Marika Gugole, Oliver Olsson, Stefano Rossi et al
Nano Letters. Vol. 21 (10), p. 4343-4350
Journal article
2021

Solid state nanopores functionalized with polymer brushes

John Andersson, Justas Svirelis, Andreas Dahlin
European Biophysics Journal. Vol. 50 (SUPPL 1), p. 68-68
Other conference contribution
2021

Plasmonic Electronic Paper

Marika Gugole, Oliver Olsson, Jolie Blake et al
International Conference on Metamaterials, Photonic Crystals and Plasmonics
Paper in proceeding
2021

Dynamically Tuneable Reflective Structural Coloration with Electroactive Conducting Polymer Nanocavities

Stefano Rossi, Oliver Olsson, Shangzhi Chen et al
Advanced Materials. Vol. 33 (49)
Journal article
2021

Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles

Albert Kamanzi, Yifei Gu, Radin Tahvildari et al
ACS Nano. Vol. 15 (12), p. 19244-19255
Journal article
2020

Large Changes in Protonation of Weak Polyelectrolyte Brushes with Salt Concentration-Implications for Protein Immobilization

Gustav Ferrand-Drake Del Castillo, Rebekah Hailes, Andreas Dahlin
Journal of Physical Chemistry Letters. Vol. 11 (13), p. 5212-5218
Journal article
2020

High-Contrast Switching of Plasmonic Structural Colors: Inorganic versus Organic Electrochromism

Marika Gugole, Oliver Olsson, Kunli Xiong et al
ACS Photonics. Vol. 7 (7), p. 1762-1772
Journal article
2020

Generic high-capacity protein capture and release by pH control

Gustav Ferrand-Drake Del Castillo, Rebekah Hailes, Zeynep Kaya et al
Chemical Communications. Vol. 56 (44), p. 5889-5892
Journal article
2019

Enzyme Immobilization in Polyelectrolyte Brushes: High Loading and Enhanced Activity Compared to Monolayers

Gustav Ferrand-Drake Del Castillo, Meike Koenig, Martin Müller et al
Langmuir. Vol. 35 (9), p. 3479-3489
Journal article
2019

Optimizing electrochromism for plasmonic electronic paper: Inorganic vs organic

Marika Gugole, Oliver Olsson, José Montero Amenedo et al
International Conference on Metamaterials, Photonic Crystals and Plasmonics, p. 760-761
Paper in proceeding
2019

Active control of plasmonic colors: emerging display technologies

Kunli Xiong, Daniel Tordera, Magnus P. Jonsson et al
Reports on Progress in Physics. Vol. 82 (2)
Review article
2019

Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature

Gustav Emilsson, Evelyn Roder, Bita Malekian et al
Frontiers in Chemistry. Vol. 7 (FEB)
Journal article
2019

Optical properties of plasmonic nanopore arrays prepared by electron beam and colloidal lithography

Bita Malekian, Kunli Xiong, Evan S.H. Kang et al
Nanoscale Advances. Vol. 1 (11), p. 4282-4289
Journal article
2018

Nanoplasmonic Sensing Architectures for Decoding Membrane Curvature-Dependent Biomacromolecular Interactions

Abdul Rahim Ferhan, J. Jackman, Bita Malekian et al
Analytical Chemistry. Vol. 90 (12), p. 7458-7466
Journal article
2018

Detecting Selective Protein Binding Inside Plasmonic Nanopores: Toward a Mimic of the Nuclear Pore Complex

Bita Malekian, Rafael L. Schoch, Timothy Robson et al
Frontiers in Chemistry. Vol. 6 (December 2018)
Journal article
2018

Polymer brushes in solid-state nanopores form an impenetrable entropic barrier for proteins

Gustav Emilsson, Kunli Xiong, Yusuke Sakiyama et al
Nanoscale. Vol. 10 (10), p. 4663-4669
Journal article
2018

Gating Protein Transport in Solid State Nanopores by Single Molecule Recognition

Gustav Emilsson, Yusuke Sakiyama, Bita Malekian et al
ACS Central Science. Vol. 4 (8), p. 1007-1014
Journal article
2018

Quantitative Analysis of Thickness and pH Actuation of Weak Polyelectrolyte Brushes

Gustav Ferrand-Drake Del Castillo, Gustav Emilsson, Andreas Dahlin
Journal of Physical Chemistry C. Vol. 122 (48), p. 27516-27527
Journal article
2018

Antibody−antigen interaction dynamics revealed by analysis of single-molecule equilibrium fluctuations on individual plasmonic nanoparticle biosensors

Srdjan Acimovic, Hana Jungová, Gustav Emilsson et al
ACS Nano. Vol. 12 (10), p. 9958-9965
Journal article
2017

Surface plasmon resonance methodology for monitoring polymerization kinetics and morphology changes of brushes-evaluated with poly(N-isopropylacrylamide)

Gustav Emilsson, Rafael L. Schoch, Philipp Oertle et al
Applied Surface Science. Vol. 396, p. 384-392
Journal article
2017

Protein exclusion is preserved by temperature sensitive PEG brushes

Rafael L. Schoch, Gustav Emilsson, Andreas Dahlin et al
Polymer. Vol. 132, p. 362-367
Journal article
2017

Fabrication and Characterization of Plasmonic Nanopores with Cavities in the Solid Support

Bita Malekian, Kunli Xiong, Gustav Emilsson et al
Sensors. Vol. 17 (6), p. Article no. 1444 -
Journal article
2017

Superior LSPR substrates based on electromagnetic decoupling for on-a-chip high-throughput label-free biosensing

Srdjan Acimovic, Hana Sipova, Gustav Emilsson et al
Light: Science and Applications. Vol. 6 (8), p. e17042-
Journal article
2017

Switchable Plasmonic Metasurfaces with High Chromaticity Containing only Abundant Metals

Kunli Xiong, Daniel Tordera, Gustav Emilsson et al
Nano Letters. Vol. 17 (11), p. 7033-7039
Journal article
2016

Dual-Wavelength Surface Plasmon Resonance for Determining the Size and Concentration of Sub-Populations of Extracellular Vesicles

Deborah Rupert, Ganesh V Shelke, Gustav Emilsson et al
Analytical Chemistry. Vol. 88 (20), p. 9980-9988
Journal article
2016

Biosensing using plasmonic nanohole arrays with small, homogenous and tunable aperture diameters

Kunli Xiong, Gustav Emilsson, Andreas Dahlin
The Analyst. Vol. 141 (12), p. 3803-3810
Journal article
2016

Plasmonic Metasurfaces with Conjugated Polymers for Flexible Electronic Paper in Color

Kunli Xiong, Gustav Emilsson, Ali Maziz et al
Advanced Materials. Vol. 28 (45), p. 9956-9960
Journal article
2015

Influence of the Evanescent Field Decay Length on the Sensitivity of Plasmonic Nanodisks and Nanoholes

Francesco Mazzotta, T. W. Johnson, Andreas Dahlin et al
ACS Photonics. Vol. 2 (2), p. 256-262
Journal article
2015

Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

Juliane Junesch, Gustav Emilsson, Kunli Xiong et al
Nanoscale. Vol. 7 (37), p. 15080-15085
Journal article
2015

Plasmon Enhanced Internal Photoemission in Antenna-Spacer-Mirror Based Au/TiO2 Nanostructures

Yurui Fang, Yang Jiao, Kunli Xiong et al
Nano Letters. Vol. 15 (6), p. 4059-4065
Journal article
2015

Sensing applications based on plasmonic nanopores: The hole story

Andreas Dahlin
The Analyst. Vol. 140 (14), p. 4748-4759
Review article
2015

Strongly Stretched Protein Resistant Poly(ethylene glycol) Brushes Prepared by Grafting-To

Gustav Emilsson, Rafael L. Schoch, Laurent Feuz et al
ACS Applied Materials & Interfaces. Vol. 7 (14), p. 7505-7515
Journal article
2014

A Thermal Plasmonic Sensor Platform: Resistive Heating of Nanohole Arrays

Mudassar Mumtaz Virk, Kunli Xiong, Mikael Svedendahl et al
Nano Letters. Vol. 14 (6), p. 3544-3549
Journal article
2014

Single-Particle Plasmon Sensing of Discrete Molecular Events: Binding Position versus Signal Variations for Different Sensor Geometries

Virginia Claudio, Andreas Dahlin, Tomasz Antosiewicz
Journal of Physical Chemistry C. Vol. 118 (13), p. 6980-6988
Journal article
2014

Plasmonic Nanopores in Metal-Insulator-Metal Films

Andreas Dahlin, Mokhtar Mapar, Kunli Xiong et al
Advanced Optical Materials. Vol. 2 (6), p. 556-564
Journal article
2013

Simultaneous electrical and plasmonic monitoring of potential induced ion adsorption on metal nanowire arrays

R. MacKenzie, C. Fraschina, B. Dielacher et al
Nanoscale. Vol. 5 (11), p. 4966-4975
Journal article
2013

Promises and challenges of nanoplasmonic devices for refractometric biosensing

Andreas Dahlin, N. J. Wittenberg, Fredrik Höök et al
Nanophotonics. Vol. 2 (2), p. 83-101
Journal article
2013

Optical Resonances in Short-Range Ordered Nanoholes in Ultrathin Aluminum/Aluminum Nitride Multilayers

Y. Ikenoya, M. Susa, J. Shi et al
Journal of Physical Chemistry C. Vol. 117 (12), p. 6373-6382
Journal article
2012

Size Matters: Problems and Advantages Associated with Highly Miniaturized Sensors

Andreas Dahlin
Sensors. Vol. 12 (3), p. 3018-3036
Review article
2012

Electrochemical plasmonic sensors

Andreas Dahlin, B. Dielacher, P. Rajendran et al
Analytical and Bioanalytical Chemistry. Vol. 402 (5), p. 1773-1784
Review article
2012

Nanoplasmonic sensing combined with artificial cell membranes

Magnus Jonsson, Andreas Dahlin, Fredrik Höök
Nanoplasmonic Sensors, p. 59-82
Book chapter
2012

Performance of nanoplasmonic biosensors

Andreas Dahlin, Martin Jonsson
Nanoplasmonic Sensors, p. 231-264
Book chapter
2012

Optical Properties of Nanohole Arrays in Metal-Dielectric Double Films Prepared by Mask-on-Metal Colloidal Lithography

Juliane Junesch, T. Sannomiya, Andreas Dahlin
ACS Nano. Vol. 6 (11), p. 10405-10415
Journal article
2012

Nanoplasmonic sensing of metal-halide complex formation and the electric double layer capacitor

Andreas Dahlin, Raphael Zahn, J. Vörös
Nanoscale. Vol. 4 (7), p. 2339-2351
Journal article
2010

Locally Functionalized Short-Range Ordered Nanoplasmonic Pores for Bioanalytical Sensing

Magnus Jonsson, Andreas Dahlin, Laurent Feuz et al
Analytical Chemistry. Vol. 82 (5), p. 2087-2094
Journal article
2009

QCM-D studies of human norovirus VLPs binding to glycosphingolipids in supported lipid bilayers reveal strain-specific characteristics.

Gustaf E Rydell, Andreas Dahlin, Fredrik Höök et al
Glycobiology. Vol. 19 (11), p. 1176-84
Journal article
2009

High-resolution microspectroscopy pf plasmonic nanostructures for miniaturized biosensing

Andreas Dahlin, Si Chen, Magnus Jonsson et al
Analytical Chemistry. Vol. 81 (16), p. 6572-6580
Journal article
2008

Nanoplasmonic biosensing with focus on short-range ordered nanoholes in thin metal films

Magnus Jonsson, Andreas Dahlin, Peter Jönsson et al
Biointerphases. Vol. 3 (3), p. FD30-FD40
Journal article
2007

Supported lipid bilayers, tethered lipid vesicles, and vesicle fusion investigated using gravimetric, plasmonic, and microscopy techniques

Fredrik Höök, Gudrun Stengel, Andreas Dahlin et al
Biointerphases. Vol. 3 (2)
Journal article
2005

Localized surface plasmon sensing of lipid-membrane-mediated biorecognition events

Andreas Dahlin, Michael Zäch, Tomas Rindzevicius et al
Journal of the American Chemical Society. Vol. 127 (14), p. 5043-5048
Journal article

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Showing 12 research projects

2022–2025

Artificial shuttle-cargo transport of proteins

Andreas Dahlin Andreas Dahlin Group
Swedish Research Council (VR)

2021–2026

Single Molecule Analysis in Nanoscale ReactionChambers SIMONANO2

Andreas Dahlin Andreas Dahlin Group
European Commission (EC)

5 publications exist
2019–2022

Plasmoniskt elektroniskt papper för videodisplay

Andreas Dahlin Andreas Dahlin Group
Kunli Xiong Andreas Dahlin Group
Swedish Research Council (VR)

2018–2022

Energisparande elektrokromiska platta hybridmaterial

Andreas Dahlin Applied Chemistry
Swedish Foundation for Strategic Research (SSF)

6 publications exist
2018–2022

SIMONANO (Single Molecule Analysis in Nanoscale Reaction)

Andreas Dahlin Applied Chemistry
Familjen Erling-Perssons stiftelse

5 publications exist
2017–2020

Polymerborstar och molekylär transport i nanokanaler

Andreas Dahlin Applied Chemistry
Swedish Research Council (VR)

1 publication exists
2016–2020

Macromolecular Gates in Nanofluidic Channels

Andreas Dahlin Applied Chemistry
Knut and Alice Wallenberg Foundation

2013–2018

Plasmonic antennas shine light on the nanoworld

Mikael Käll Bionanophotonics
Kasper Moth-Poulsen Polymer Technology
Fredrik Höök Biological Physics
Eva Olsson Eva Olsson Group
Peter Johansson Bionanophotonics
Andreas Dahlin Applied Chemistry
Christoph Langhammer Chemical Physics
Alexander Dmitriev Bionanophotonics
Knut and Alice Wallenberg Foundation

2 publications exist
2013–2016

Active Nanopores Functionalized with Responsive Polymers

Andreas Dahlin Applied Chemistry
Swedish Research Council (VR)

2012–2017

Funktionella elektromagnetiska metamaterial & optisk sensing

Mikael Käll Bionanophotonics
Alexander Dmitriev Bionanophotonics
Christoph Langhammer Chemical Physics
Andreas Dahlin Applied Chemistry
Fredrik Höök Biological Physics
Swedish Foundation for Strategic Research (SSF)

2 publications exist
2012–2016

Active Polymer-Functionalized Nanopores (ACTIVE NANOPORES)

Andreas Dahlin Applied Chemistry
European Commission (EC)

2012–2015

Elektrokemiska portar i vätskefyllda nanokanaler

Andreas Dahlin Applied Chemistry
Swedish Foundation for Strategic Research (SSF)

There might be more projects where Andreas Dahlin participates, but you have to be logged in as a Chalmers employee to see them.