Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature
Journal article, 2015

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Author

Juliane Junesch

Chalmers, Applied Physics, Biological Physics

Gustav Emilsson

Chalmers, Applied Physics, Bionanophotonics

Kunli Xiong

Chalmers, Applied Physics, Bionanophotonics

S. Kumar

University of Minnesota

T. Sannomiya

Tokyo Institute of Technology

Hudson Pace

Chalmers, Applied Physics, Biological Physics

J. Vörös

Swiss Federal Institute of Technology in Zürich (ETH)

S. H. Oh

University of Minnesota

Marta Bally

Chalmers, Applied Physics, Biological Physics

Andreas Dahlin

Chalmers, Applied Physics, Biological Physics

Nanoscale

2040-3364 (ISSN)

Vol. 7 37 15080-15085

Subject Categories

Biochemistry and Molecular Biology

Chemical Engineering

DOI

10.1039/c5nr04208a

PubMed

26351000

More information

Latest update

11/30/2018