Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature
Journal article, 2015
The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.
Author
Juliane Junesch
Chalmers, Applied Physics, Biological Physics
Gustav Emilsson
Chalmers, Applied Physics, Bionanophotonics
Kunli Xiong
Chalmers, Applied Physics, Bionanophotonics
S. Kumar
University of Minnesota
T. Sannomiya
Tokyo Institute of Technology
Hudson Pace
Chalmers, Applied Physics, Biological Physics
J. Vörös
Swiss Federal Institute of Technology in Zürich (ETH)
S. H. Oh
University of Minnesota
Marta Bally
Chalmers, Applied Physics, Biological Physics
Andreas Dahlin
Chalmers, Applied Physics, Biological Physics
Nanoscale
2040-3364 (ISSN) 2040-3372 (eISSN)
Vol. 7 37 15080-15085Subject Categories
Biochemistry and Molecular Biology
Chemical Engineering
DOI
10.1039/c5nr04208a
PubMed
26351000