Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature
Artikel i vetenskaplig tidskrift, 2015

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Författare

Juliane Junesch

Chalmers, Teknisk fysik, Biologisk fysik

Gustav Emilsson

Chalmers, Teknisk fysik, Bionanofotonik

K. Xiong

Chalmers University of Technology

S. Kumar

University of Minnesota

T. Sannomiya

Tokyo Institute of Technology

Hudson Pace

Chalmers, Teknisk fysik, Biologisk fysik

J. Vörös

Eidgenössische Technische Hochschule Zürich (ETH)

S. H. Oh

University of Minnesota

Marta Bally

Chalmers, Teknisk fysik, Biologisk fysik

Andreas Dahlin

Chalmers, Teknisk fysik, Biologisk fysik

Nanoscale

2040-3364 (ISSN)

Vol. 7 15080-15085

Ämneskategorier

Biokemi och molekylärbiologi

Kemiteknik

DOI

10.1039/c5nr04208a

PubMed

26351000