Stem cell responses to plasma surface modified electrospun polyurethane scaffolds.
Artikel i vetenskaplig tidskrift, 2014

The topographical effects from functional materials on stem cell behavior are currently of interest in tissue engineering and regenerative medicine. Here we investigate the influence of argon, oxygen, and hydrogen plasma surface modification of electrospun polyurethane fibers on human embryonic stem cell (hESC) and rat postnatal neural stem cell (NSC) responses. The plasma gases were found to induce three combinations of fiber surface functionalities and roughness textures. On randomly oriented fibers, plasma treatments lead to substantially increased hESC attachment and proliferation as compared to native fibers. Argon plasma was found to induce the most optimal combination of surface functionality and roughness for cell expansion. Contact guided migration of cells and alignment of cell processes were observed on aligned fibers. Neuronal differentiation around 5% was found for all samples and was not significantly affected by the induced variations of surface functional group distribution or individual fiber topography.

Polyurethane

Stem cell

Scaffold

Surface modification

Författare

[Person d82a41f1-b05d-46ba-a102-4f6e6b25f18d not found]

Chalmers, Teknisk fysik, Elektronikmaterial och system

[Person 92a27fa2-79fa-4df8-acdd-31cca74e4410 not found]

Göteborgs universitet

[Person 7eadef94-cb3b-4f5e-9316-375d4c48fd42 not found]

Göteborgs universitet

[Person 0d49d9aa-f30b-4962-89eb-326014f0c306 not found]

Göteborgs universitet

[Person becce727-9c07-4285-8487-ae55b6538016 not found]

Chalmers, Teknisk fysik, Elektronikmaterial och system

[Person 531eb2ac-01ef-4bff-9eb4-43b6d58b4d83 not found]

Göteborgs universitet

Nanomedicine: Nanotechnology, Biology, and Medicine

1549-9634 (ISSN) 1549-9642 (eISSN)

Vol. 10 5 949-958

Ämneskategorier

Neurovetenskaper

Biomaterialvetenskap

DOI

10.1016/j.nano.2014.01.010

PubMed

24524929

Mer information

Skapat

2017-10-07