Toward Unimolecular Micelles with Tunable Dimensions Using Hyperbranched Dendritic-Linear Polymers
Artikel i vetenskaplig tidskrift, 2014

A library of amphiphilic, hyperbranched dendritic-linear polymers (HBDLPs) are successfully synthesized, and evaluated as potential unimolecular micelles. Hyperbranched macroinitiators (HBMI), extended with poly(ethylene glycol) methacrylate (P(OEGMA)), are afforded via a combination of self-condensing vinyl (co)polymerization (SCV(C)P) and atom transfer radical polymerization (ATRP), providing a versatile two-step synthetic route. The HBDLP architecture and chain lengths are varied, and the effect on the nanoparticle (NP) stability and properties are evaluated. The HBDLPs form predominantly stable and spherical NPs, and the NP dimensions could be tailored by the HBDLP characteristics. The NPs formed are of high molecular weight, and their stability varies with the properties of the corresponding HBDLP. Too small dendritic segment, or too low degree of PEGylation, results to some extent in NP aggregation, while higher molecular weight HBDLPs, with a high amount of hydrophilic segments, appears to form discrete unimolecular micelles. The versatility of the platform is further demonstrated by the convenience of forming a HBDLP. with a more complex, linear copolymer extension instead of P(OEGMA).

NANOPARTICLES

IN-VITRO EVALUATION

AB-ASTERISK MONOMERS

DRUG-DELIVERY

CONDENSING VINYL POLYMERIZATION

1970

BLOCK-COPOLYMER HYBRIDS

JOURNAL OF CHEMICAL PHYSICS

BREAST-CANCER CELLS

V52

NNER JE

POLYMERS

LIVING RADICAL POLYMERIZATION

P2523

STAR

BIOLOGICAL APPLICATIONS

Författare

C. Porsch

Kungliga Tekniska Högskolan (KTH)

Y. N. Zhang

Karolinska Institutet

C. Ducani

Karolinska Institutet

francisco Vilaplana

Kungliga Tekniska Högskolan (KTH)

Lars Nordstierna

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

A. M. Nystrom

Karolinska Institutet

E. Malmstrom

Kungliga Tekniska Högskolan (KTH)

Biomacromolecules

1525-7797 (ISSN) 1526-4602 (eISSN)

Vol. 15 2235-2245

Ämneskategorier

Polymerkemi

DOI

10.1021/bm5003637