Robustness study of the different immittance spectra and frequency ranges in bioimpedance spectroscopy analysis for assessment of total body composition.
Artikel i vetenskaplig tidskrift, 2014

The estimation of body fluids is a useful and common practice for assessment of disease status and therapy outcomes. Electrical bioimpedance spectroscopy (EBIS) methods are noninvasive, inexpensive and efficient alternatives for determination of body fluids. One of the main source of errors in EBIS measurements in the estimation of body fluids is capacitive coupling. In this paper an analysis of capacitive coupling in EBIS measurements was performed and the robustness of the different immittance spectra against it tested. On simulations the conductance (G) spectrum presented the smallest overall error, among all immittance spectra, in the estimation of the impedance parameters used to estimate body fluids. Afterwards the frequency range of 10-500 kHz showed to be the most robust band of the G spectrum. The accuracy of body fluid estimations from the resulting parameters that utilized G spectrum and parameters provided by the measuring device were tested on EBIS clinical measurements from growth hormone replacement therapy patients against estimations performed with dilution methods. Regarding extracellular fluid, the correlation between each EBIS method and dilution was 0.93 with limits of agreement of 1.06 ± 2.95 l for the device, 1.10 ± 2.94 l for G [10-500 kHz] and 1.04 ± 2.94 l for G [5-1000 kHz]. Regarding intracellular fluid, the correlation between dilution and the device was 0.91, same as for G [10-500 kHz] and 0.92 for G [5-1000 kHz]. Limits of agreement were 0.12 ± 4.46 l for the device, 0.09 ± 4.45 for G [10-500 kHz] and 0.04 ± 4.58 for G [5-1000 kHz]. Such close results between the EBIS methods validate the proposed approach of using G spectrum for initial Cole characterization and posterior clinical estimation of body fluids status.

Feasibility Studies

Algorithms

Electric Capacitance

Female

Male

Extracellular Fluid

Regression Analysis

physiology

Models

Middle Aged

drug effects

Factual

Hormone Replacement Therapy

physiology

Humans

Body Composition

therapeutic use

Growth Hormone

Databases

Computer Simulation

physiology

Electric Impedance

Body Fluids

methods

Intracellular Fluid

Biological

drug effects

Dielectric Spectroscopy

Författare

R Buendia

Fernando Seoane Martinez

Ingvar Bosaeus

Göteborgs universitet

R Gil-Pita

Gudmundur Johannsson

Lars Ellegård

Kaj Lindecrantz

Physiological measurement

1361-6579 (ISSN)

Vol. 35 7 1373-95

Ämneskategorier

Klinisk medicin

DOI

10.1088/0967-3334/35/7/1373

PubMed

24854791