COX-2 regulation and TUNEL-positive cell death differ between genders in the secondary inflammatory response following experimental penetrating focal brain injury in rats.
Artikel i vetenskaplig tidskrift, 2015

Traumatic brain injury is followed by secondary neuronal degeneration, largely dependent on an inflammatory response. This response is probably gender specific, since females are better protected than males in experimental models. The reasons are not fully known. We examined aspects of the inflammatory response following experimental TBI in male and female rats to explore possible gender differences at 24 h and 72 h after trauma, times of peak histological inflammation and neuronal degeneration.

iNOS

Gender

TBI

Secondary inflammation

COX-2

Sex

Författare

Mattias Günther

Karolinska Institutet

Stefan Plantman

Karolinska Institutet

Johan Davidsson

Chalmers, Tillämpad mekanik, Fordonssäkerhet

Maria Angéria

Karolinska Institutet

Tiit Mathiesen

Karolinska Institutet

Mårten Risling

Karolinska Institutet

Acta Neurochirurgica

0001-6268 (ISSN) 0942-0940 (eISSN)

Vol. 157 649-659

Drivkrafter

Hållbar utveckling

Ämneskategorier

Neurovetenskaper

DOI

10.1007/s00701-014-2331-2

PubMed

25597483