Biodegradable nanofilms on microcapsules for controlled release of drugs to infected chronic wounds
Artikel i vetenskaplig tidskrift, 2015

Systemic antibiotic and topical antimicrobial overexposure strongly contributes to the development of bacterial resistance. We have assembled nanofilms as a lid for drugs, which respond to the Staphylococcus aureus protease V8, while remaining intact when exposed to a human wound protease. Hollow microcapsules, loaded with a model drug and with the nanofilm as shell were assembled by template assisted assembly. With a poly-L-glutamic acid-based film, the Glu-X specific V8 caused the film to degrade, leading to release of the model drug, while the human wound protease did not affect the microcapsules. This is an example of triggered release of an active with the wound infection being the trigger.

controlled release

microcapsule

Nanofilm

infection

Staphylococcus aureus

polyelectrolyte

enzymatic degradation

Författare

Marina Craig

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Teknisk ytkemi

SuMo Biomaterials

Erich Schuster

Swedish Institute for Food and Biotechnology

Krister Holmberg

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Teknisk ytkemi

Materials Today: Proceedings

2214-7853 (eISSN)

Vol. 1 118-125

Ämneskategorier

Kemi

Styrkeområden

Materialvetenskap

DOI

10.1016/j.matpr.2015.04.023