From next-generation sequencing to systematic modeling of the gut microbiome
Artikel i vetenskaplig tidskrift, 2015

Changes in the human gut microbiome are associated with altered human metabolism and health, yet the mechanisms of interactions between microbial species and human metabolism have not been clearly elucidated. Next-generation sequencing has revolutionized the human gut microbiome research, but most current applications concentrate on studying the microbial diversity of communities and have at best provided associations between specific gut bacteria and human health. However, little is known about the inner metabolic mechanisms in the gut ecosystem. Here we review recent progress in modeling the metabolic interactions of gut microbiome, with special focus on the utilization of metabolic modeling to infer host-microbe interactions and microbial species interactions. The systematic modeling of metabolic interactions could provide a predictive understanding of gut microbiome, and pave the way to synthetic microbiota design and personalized-microbiome medicine and healthcare. Finally, we discuss the integration of metabolic modeling and gut microbiome engineering, which offer a new way to explore metabolic interactions across members of the gut microbiota.

methanogenesis

phenotype

Review

human

Personalized medicine

intestine flora

Systematic modeling

microbial metabolism

Next-generation sequencing

molecular interaction

metagenomics

Metabolic modeling

next generation sequencing

Gut microbiome

nonhuman

model

Species interactome

microbiome

microbial community

Författare

Boyang Ji

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Frontiers in Genetics

1664-8021 (ISSN)

Vol. 6 JUN

Ämneskategorier

Biologiska vetenskaper

Styrkeområden

Livsvetenskaper och teknik

DOI

10.3389/fgene.2015.00219