Feasibility of quantitative determination of doxorubicin with surface-enhanced Raman spectroscopy
Artikel i vetenskaplig tidskrift, 2001

Surface-enhanced Raman spectroscopy (SERS) was performed using excitation at 488 nm in a blood plasma-doxorubicin-silver colloid system. With a blood plasma content of 1%, a partial least-squares calibration of the doxorubicin was made in the 10-750 nM range. Predictions for a test set generated a root mean square error of prediction of 70 nM. The use of SERS and chemometrics in complex systems made it possible to use the highly informative Raman signals even at low concentrations without the need for sample pretreatment such as extraction. Copyright © 2001 John Wiley & Sons, Ltd.


Anders Lorén

Chalmers, Institutionen för kemi och biovetenskap

C. Eliasson

Mats Josefson

K.V.G.K. Murty

Mikael Käll

Chalmers, Teknisk fysik

Jonas Abrahamsson

Göteborgs universitet

Katarina Abrahamsson

Chalmers, Institutionen för kemi och biovetenskap, Analytisk och marin kemi

Journal of Raman Spectroscopy

0377-0486 (ISSN) 1097-4555 (eISSN)

Vol. 32 11 971-974





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