Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.
Artikel i vetenskaplig tidskrift, 2015

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

multocomnpartmental modeling

apoB

kinetics

stable isotopes

very low density lipoproteins

Författare

Martin Adiels

Göteborgs universitet

Adil Mardinoglu

Chalmers, Biologi och bioteknik, Systembiologi

Marja-Riitta Taskinen

Helsinki University Central Hospital

Jan Borén

Göteborgs universitet

Frontiers in Physiology

1664-042X (ISSN)

Vol. 6 NOV 342- 342

Ämneskategorier

Medicinska grundvetenskaper

Klinisk medicin

Bioinformatik (beräkningsbiologi)

Bioinformatik och systembiologi

DOI

10.3389/fphys.2015.00342

PubMed

26635628

Mer information

Skapat

2017-10-08