Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution
Artikel i vetenskaplig tidskrift, 2016

Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models. Microarray analysis revealed training-induced up-regulation of pathways associated with immune function. NK cell infiltration was significantly increased in tumors from running mice, whereas depletion of NK cells enhanced tumor growth and blunted the beneficial effects of exercise. Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of beta-adrenergic signaling blunted training-dependent tumor inhibition. Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation. Together, these results link exercise, epinephrine, and IL-6 to NK cell mobilization and redistribution, and ultimately to control of tumor growth.

missing-self-recognition

il-6

cytokines

muscle

inflammation

phenotype

cancer

natural-killer-cells

exercise

physical-activity

Författare

L. Pedersen

Köpenhamns universitet

M. Idorn

Copenhagen University Hospital

G. H. Olofsson

Copenhagen University Hospital

B. Lauenborg

Köpenhamns universitet

Intawat Nookaew

Chalmers, Biologi och bioteknik, Systembiologi

R. H. Hansen

Amtssygehuset i Herlev

H. H. Johannesen

Amtssygehuset i Herlev

J. C. Becker

Universitats Klinikum Essen und Medizinische Fakultat

K. S. Pedersen

Köpenhamns universitet

C. Dethlefsen

Köpenhamns universitet

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

J. Gehl

Copenhagen University Hospital

B. K. Pedersen

Köpenhamns universitet

P. T. Straten

Köpenhamns universitet

Copenhagen University Hospital

P. Hojman

Copenhagen University Hospital

Köpenhamns universitet

Cell Metabolism

1550-4131 (ISSN) 19327420 (eISSN)

Vol. 23 3 554-562

Ämneskategorier

Cellbiologi

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

DOI

10.1016/j.cmet.2016.01.011

PubMed

26895752

Mer information

Senast uppdaterat

2024-08-14