Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution
Artikel i vetenskaplig tidskrift, 2016

Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models. Microarray analysis revealed training-induced up-regulation of pathways associated with immune function. NK cell infiltration was significantly increased in tumors from running mice, whereas depletion of NK cells enhanced tumor growth and blunted the beneficial effects of exercise. Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of beta-adrenergic signaling blunted training-dependent tumor inhibition. Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation. Together, these results link exercise, epinephrine, and IL-6 to NK cell mobilization and redistribution, and ultimately to control of tumor growth.

inflammation

missing-self-recognition

il-6

natural-killer-cells

physical-activity

muscle

exercise

phenotype

cytokines

cancer

Författare

L. Pedersen

Köbenhavns Universitet

M. Idorn

Copenhagen University Hospital

G. H. Olofsson

Copenhagen University Hospital

B. Lauenborg

Köbenhavns Universitet

Intawat Nookaew

Chalmers, Biologi och bioteknik, Systembiologi

R. H. Hansen

Amtssygehuset i Herlev

H. H. Johannesen

Amtssygehuset i Herlev

J. C. Becker

Universitats Klinikum Essen und Medizinische Fakultat

K. S. Pedersen

Köbenhavns Universitet

C. Dethlefsen

Köbenhavns Universitet

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

J. Gehl

Copenhagen University Hospital

B. K. Pedersen

Köbenhavns Universitet

P. T. Straten

Köbenhavns Universitet

Copenhagen University Hospital

P. Hojman

Köbenhavns Universitet

Copenhagen University Hospital

Cell Metabolism

1550-4131 (ISSN)

Vol. 23 3 554-562

Ämneskategorier

Cellbiologi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1016/j.cmet.2016.01.011

PubMed

26895752