Topographically Flat Nanoplasmonic Sensor Chips for Biosensing and Materials Science
Artikel i vetenskaplig tidskrift, 2017

Nanoplasmonic sensors typically comprise arrangements of noble metal nanoparticles on a dielectric support. Thus they are intrinsically characterized by surface topography with corrugations at the 10–100 nm length scale. While irrelevant in some bio- and chemosensing applications, it is also to be expected that the surface topography significantly influences the interaction between solids, fluids, nanoparticles and (bio)molecules, and the nanoplasmonic sensor surface. To address this issue, we present a wafer-scale nanolithography-based fabrication approach for high-temperature compatible, chemically inert and topographically flat and laterally homogeneous nanoplasmonic sensor chips. We demonstrate their sensing performance on three different examples, for which we also carry out a direct comparison with a traditional nanoplasmonic sensor with representative surface corrugation. Specifically, we (i) quantify the film-thickness dependence of the glass transition temperature in poly(methyl metacrylate) thin films, (ii) characterize the adsorption and specific binding kinetics of the avidin – b-BSA protein system and (iii) analyze supported lipid bilayer formation on SiO2 surfaces.

supported lipid bilayer formation

flat topography

surface corrugation

b-BSA specific binding

avidin adsorption

nanoplasmonic sensing (NPS)

polymer glass transition

Författare

Ferry Nugroho

Chalmers, Fysik, Kemisk fysik

Rickard Frost

Chalmers, Fysik, Kemisk fysik

Tomasz Antosiewicz

Chalmers, Fysik, Bionanofotonik

Joachim Fritzsche

Chalmers, Fysik, Kemisk fysik

Elin Maria Kristina Larsson

Insplorion AB

Christoph Langhammer

Chalmers, Fysik, Kemisk fysik

ACS Sensors

2379-3694 (eISSN)

Vol. 2 1 119-127

Ämneskategorier

Fysik

DOI

10.1021/acssensors.6b00612