Mathematical aspects of the regulation of gene transcription by promoters
Artikel i vetenskaplig tidskrift, 2017

Although the transcriptional regulation of gene expression has been a subject of intense experimental and theoretical studies over the past several decades, the understanding of this process is still incomplete. In particular, the models focused on the function of transcription factors usually take into account only the lateral interactions between them in the ground bound state. The rates of attachment and detachment of transcription factors on the promoter sites depend, however, also on the lateral interactions in the activated state. I present general equations describing the effect of both these interactions on the rates of attachment and detachment and illustrate their role in the kinetics of gene expression by using a generic model focused on the function of a gene regulated via two promoter sites. The corresponding analytical treatment and Monte Carlo simulations show that the lateral interaction in the activated state is significant if the genes are expressed in the regime of stochastic bursts of high and low transcriptional activity and RNA and protein populations. In particular, the duration and shape of bursts depend on this interaction.

Transcriptional regulation

Lateral interactions

Bursts

Stochastic kinetics

Transcriptional factors

Theory of rate processes

Författare

Vladimir Zhdanov

Chalmers, Fysik, Biologisk fysik

Mathematical Biosciences

0025-5564 (ISSN)

Vol. 283 84-90

Drivkrafter

Hållbar utveckling

Ämneskategorier

Biologiska vetenskaper

DOI

10.1016/j.mbs.2016.11.007

Mer information

Skapat

2017-10-07