Mucosal Vaccine Development Based on Liposome Technology
Artikel i vetenskaplig tidskrift, 2016

Immune protection against infectious diseases is most effective if located at the portal of entry of the pathogen. Hence, there is an increasing demand for vaccine formulations that can induce strong protective immunity following oral, respiratory, or genital tract administration. At present, only few mucosal vaccines are found on the market, but recent technological advancements and a better understanding of the principles that govern priming of mucosal immune responses have contributed to a more optimistic view on the future of mucosal vaccines. Compared to live attenuated vaccines, subcomponent vaccines, most often protein-based, are considered safer, more stable, and less complicated to manufacture, but they require the addition of nontoxic and clinically safe adjuvants to be effective. In addition, another limiting factor is the large antigen dose that usually is required for mucosal vaccines. Therefore, the combination ofmucosal adjuvantswith the recent progress in nanoparticle technology provides an attractive solution to these problems. In particular, the liposome technology is ideal for combining protein antigen and adjuvant into an effective mucosal vaccine. Here, we describe and discuss recent progress in nanoparticle formulations using various types of liposomes that convey strong promise for the successful development of the next generation of mucosal vaccines.

protein corona

immunoadjuvant activity

in-vitro

1995

delivery-system

cationic liposomes

intranasal

mediated immune-responses

oral vaccine

vaccine

immunization

v13

p155

haan a

antibody-responses

influenza subunit vaccine

Immunology

Författare

V. Bernasconi

Göteborgs universitet

Karin Norling

Chalmers, Fysik, Biologisk fysik

Marta Bally

Chalmers, Fysik, Biologisk fysik

Fredrik Höök

Chalmers, Fysik, Biologisk fysik

N. Y. Lycke

Göteborgs universitet

Journal of Immunology Research

2314-8861 (ISSN) 2314-7156 (eISSN)

Ämneskategorier

Fysik

Fundament

Grundläggande vetenskaper

DOI

10.1155/2016/5482087

Mer information

Senast uppdaterat

2018-03-07