A high rate of non-compliance confounds the study of whole grains and weight maintenance in a randomised intervention trial-the case for greater use of dietary biomarkers in nutrition intervention studies
Artikel i övriga tidskrifter, 2017

Observational studies consistently find an inverse relationship between whole-grain intake and weight gain. We aimed to confirm this in an open-label researcher-blinded parallel design randomised trial. A total of 179 overweight/obese women with a habitually low whole-grain intake (<16 g/day) were randomised to a weight maintenance diet with refined-grain (RG) or whole-grain (WG) foods (80 g/day) for 12 weeks after an initial weight loss program over 8 weeks. Body weight and composition was assessed at baseline, after the initial weight loss, and after the 12-week dietary intervention. During the 12-week dietary intervention phase, there were no group differences in changes in body weight and total fat mass %, whereas abdominal fat mass tended to increase more during the dietary intervention phase in the WG compared to the RG group (0.7 (SD 3.6) vs. ?0.3 (SD 3.8) %; p = 0.052). Plasma alkylresorcinol concentrations, biomarkers of wholegrain wheat and rye intake, indicated poor compliance, particularly in the WG group, where >60% of participants had alkylresorcinol concentrations below 70 nmol/L, a concentration indicating low or no intake of whole-grain wheat. Further, weight regain was lower than expected in both intervention groups, further supporting a lack of compliance to the post-weight-loss diet. The rate of compliance was too low to conclude any effect of whole grain on weight maintenance, and reinforces the need to use objective measures of compliance in nutrition intervention studies.

Weight maintenance

Compliance

Whole grain

Alkylresorcinols

Biomarkers

Författare

M. Kristensen

Köbenhavns Universitet

Xavier Pelletier

Optimed Clinical Research

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

F. Thielecke

T2 Goodness Ltd.

Cereal Partners Worldwide

Nutrients

2072-6643 (ISSN)

Vol. 9 1 55- 55

Styrkeområden

Livsvetenskaper och teknik

Ämneskategorier

Näringslära

DOI

10.3390/nu9010055