3D skeletal uptake of F-18 sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer
Artikel i vetenskaplig tidskrift, 2017

Background: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer. Methods: NaF PET/CT and bone scans were studied in 48 patients with prostate cancer. Automated segmentation of the thoracic and lumbar spines, sacrum, pelvis, ribs, scapulae, clavicles, and sternum were made in the CT images. Hotspots in the PET images were selected using both a manual and an automated method. The volume of each hotspot localized in the skeleton in the corresponding CT image was calculated. Two PET/CT indices, based on manual (manual PET index) and automatic segmenting using a threshold of SUV 15 (automated PET15 index), were calculated by dividing the sum of all hotspot volumes with the volume of all segmented bones. BSI values were obtained using a software for automated calculations. Results: BSI, manual PET index, and automated PET15 index were all significantly associated with OS and concordance indices were 0.68, 0.69, and 0.70, respectively. The median BSI was 0.39 and patients with a BSI > 0.39 had a significantly shorter median survival time than patients with a BSI < 0.39 (2.3 years vs not reached after 5 years of follow-up [p = 0.01]). The median manual PET index was 0.53 and patients with a manual PET index > 0.53 had a significantly shorter median survival time than patients with a manual PET index < 0.53 (2.5 years vs not reached after 5 years of follow-up [p < 0.001]). The median automated PET15 index was 0.11 and patients with an automated PET15 index > 0.11 had a significantly shorter median survival time than patients with an automated PET15 index < 0.11 (2.3 years vs not reached after 5 years of follow-up [p < 0.001]). Conclusions: PET/CT indices based on NaF PET/CT are correlated to BSI and significantly associated with overall survival in patients with prostate cancer.

Imaging biomarker

Prostate cancer

Sodium fluoride

Bone scan index

PET/CT

Författare

S. L. Belal

Lunds universitet

M. Sadik

Sahlgrenska universitetssjukhuset

R. Kaboteh

Sahlgrenska universitetssjukhuset

N. Hasani

Sahlgrenska universitetssjukhuset

Olof Enqvist

Chalmers, Signaler och system, Signalbehandling och medicinsk teknik, Digitala bildsystem och bildanalys

L. Svarm

Eigenvision AB

Fredrik Kahl

Chalmers, Signaler och system, Signalbehandling och medicinsk teknik, Digitala bildsystem och bildanalys

J. Simonsen

Odense Universitetshospital

M. H. Poulsen

Odense Universitetshospital

M. Ohlsson

Lunds universitet

P. F. Hoilund-Carlsen

Odense Universitetshospital

L. Edenbrandt

Sahlgrenska universitetssjukhuset

E. Tragardh

Lunds universitet

EJNMMI Research

2191-219X (ISSN)

Vol. 7 1 15

Ämneskategorier

Kirurgi

Radiologi och bildbehandling

Medicinsk bildbehandling

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1186/s13550-017-0264-5

Mer information

Senast uppdaterat

2018-04-17