Drug delivery from hydrogels: A general framework for the release modeling
Artikel i vetenskaplig tidskrift, 2017

The controlled delivery of drugs, including siRNAs, can be effectively obtained using Hydrogel- Based Drugs Delivery Systems (HB-DDSs). Successful design of HB-DDSs requires the knowledge of the mechanisms that influence drug release. The modeling of the physical phenomena involved could help in the development and optimization of HB-DDS, sensibly reducing the time and costs required by a trial-and-error procedures. The modeling is rather complex because of the presence of several, synergistic and competing, transport phenomena. In this work a general framework useful for modeling the HB-DDS has been derived and it is proposed, coupling and homogenizing the literature models. It is shown that all of them can be traced back to two different approaches: multiphasic models and multicomponent mixture models. In the first one the hydrogel is seen as constituted by different phases, the behavior of each one being described by their own mass and momentum conservation equations. In the second approach, the hydrogel is considered as made of one phase composed by several components.

Hydrogels

siRNAs

Mathematical modeling

Controlled drug delivery

Författare

Diego Caccavo

Universita degli Studi di Salerno

Sara Cascone

Universita degli Studi di Salerno

Gaetano Lamberti

Universita degli Studi di Salerno

Anna Angela Barba

Universita degli Studi di Salerno

Anette Larsson

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Farmaceutisk teknologi

Current Drug Delivery

1567-2018 (ISSN)

Vol. 14 2 179-189

Ämneskategorier

Farmaceutisk vetenskap

Styrkeområden

Produktion

Materialvetenskap

DOI

10.2174/1567201813666160808102106

Mer information

Senast uppdaterat

2018-10-16