Oxidative organocatalytic chemoselective: N -acylation of heterocycles with aromatic and conjugated aldehydes
Artikel i vetenskaplig tidskrift, 2017

Selective acylation of indoles is cumbersome often involving the need for sensitive and reactive acyl chloride derivatives or coupling reagents. Here we report a mild, functional group tolerant and highly chemoselective oxidative carbene catalyzed N-acylation of indoles with aldehydes. The acylation has a broad substrate scope and is compatible with substituents on both the aldehyde and the indole reaction partner. Furthermore, aza-heterocycles such as pyrrole and indazole can also be used as nucleophiles in this reaction providing the corresponding amide congeners in good yield.

Författare

Linda Ta

Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Henrik Sundén

Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Chemical Communications

1359-7345 (ISSN)

Vol. 54 531-534

Ämneskategorier

Oorganisk kemi

Biokatalys och enzymteknik

Organisk kemi

DOI

10.1039/c7cc08672e