Heart rate variability characteristics of patients with irritable bowel syndrome and associations with symptoms
Artikel i vetenskaplig tidskrift, 2018

Background: Disturbed brain-gut interactions are assumed to be of importance for symptom generation in patients with irritable bowel syndrome (IBS). The autonomic nervous system (ANS) is part of the bidirectional brain-gut communication, but previous studies in IBS show diverging results. We aimed to identify subgroups of IBS patients with distinct ANS characteristics differentiating them from healthy controls (HC), and to study associations between ANS status and symptoms. Methods: Heart rate variability (HRV) was measured in IBS patients and HC (Holter monitoring: supine and standing positions with controlled respiration and ambulatory 24-hour period). Frequency (5 minutes, supine, standing) and time domains (24 hours, day, night) were analyzed. Validated questionnaires were used to measure gastrointestinal and psychological symptoms in patients. Patients and HC were compared on a univariate and multivariate level (principal component analysis [PCA] and orthogonal partial least squares discriminatory analysis (OPLS-DA)). Key Results: We analyzed 158 IBS patients (Rome III) and 39 HC. Patients differed significantly from HC in HRV parameters during daytime and in standing position. In the PCA, a majority of patients overlapped with HC, but the weighted means differed (P <.01). A subset of patients (n = 30; 19%) with an aberrant global HRV profile was identified through PCA and OPLS-DA; these patients reported more severe symptoms of frequent (P <.05) and loose stools (P =.03), as well as urgency (P =.01). Conclusions and Inferences: Altered ANS function was demonstrated in patients with IBS, and this might be of particular relevance for symptoms in a subset of the patients.

multivariate analysis

brain-gut axis

autonomic nervous system

heart rate variability

irritable bowel syndrome

Författare

A. Polster

Sahlgrenska universitetssjukhuset

P. Friberg

Sahlgrenska akademin

V. Gunterberg

Sahlgrenska universitetssjukhuset

L. Öhman

Sahlgrenska akademin

B. Le Nevé

Groupe Danone

H. Törnblom

Sahlgrenska universitetssjukhuset

Marija Cvijovic

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

M. Simren

The University of North Carolina at Chapel Hill

Sahlgrenska universitetssjukhuset

Neurogastroenterology and Motility

1350-1925 (ISSN)

Vol. 30 7 e13320

Ämneskategorier

Allmänmedicin

Gastroenterologi

Kardiologi

DOI

10.1111/nmo.13320

Mer information

Senast uppdaterat

2018-07-04