Modeling the mechanics and the transport phenomena in hydrogels
Kapitel i bok, 2018

Hydrogels are polymeric materials widely used in pharmaceutical and biomedical applications. Their uses can be improved by modeling their behavior, in particular the mechanical phenomena and the transport phenomena. The scope of this chapter is to propose a model, simple enough and with a limited number of parameters to be determined, able to capture the full behavior of a swelling hydrogel, with the aim of describing the drug release process as well as—in principle—any other application of hydrogels. The model was derived recalling the basics of the continuum mechanics, the possible approaches to estimate the Helmholtz free energy, and then writing the transport and constitutive equations for a poroelastic material, and for a more realistic poroviscoelastic material (by adding the standard linear solid model as the rheological model). A full extension to multicomponent systems, to describe the drug release phenomenon, is proposed along with a sensitivity analysis (free-swelling simulation by changing the model parameters).

Hydrogels

Viscoelasticity

Transport phenomena

Mechanics

Modeling

Drug release

Poroviscoelasticity

Författare

D. Caccavo

Universita degli Studi di Salerno

Antonella Vietri

Universita degli Studi di Salerno

Gaetano Lamberti

Universita degli Studi di Salerno

Anna Angela Barba

Universita degli Studi di Salerno

Anette Larsson

Anette Larsson Group

Computer Aided Chemical Engineering

357-383

Ämneskategorier

Teknisk mekanik

Sannolikhetsteori och statistik

Reglerteknik

Styrkeområden

Produktion

Materialvetenskap

DOI

10.1016/B978-0-444-63964-6.00012-X

Mer information

Senast uppdaterat

2018-10-16