Plasma cells and Fc receptors in human adipose tissue--lipogenic and anti-inflammatory effects of immunoglobulins on adipocytes
Artikel i vetenskaplig tidskrift, 2006

We have previously reported high immunoglobulin expression in human omental adipose tissue. The aim of this work was to investigate plasma cell density and Fc receptor (FcR) expression in human adipose tissue depots and in vitro effects of immunoglobulins on adipocyte function. Plasma cell density was higher in the visceral compared to the subcutaneous depot (10.0+/-1.56% and 5.2+/-0.98%, respectively, n=20, p<0.05). Microarray analysis revealed expression of four FcR genes in adipose tissue; FCGR2A, FCGR2B, FCER1G, and FCGRT. FCGR2A was highly expressed in adipocytes in both depots and this was verified by immunohistochemistry. Expression of IL-1beta and IL-6 was markedly reduced in adipocytes after incubation with the Fc moiety of immunoglobulin G (Fc) (p<0.01). Furthermore, Fc stimulated adipocyte lipogenesis as potently as insulin (p<0.05), but did not influence lipolysis. In conclusion, immunoglobulins produced by plasma cells in human adipose tissue could influence adipocyte metabolism and cytokine production.

Adipocytes/immunology

Male

Humans

Female

Adipose Tissue/*cytology/*immunology

Plasma Cells/*immunology

Omentum/cytology

Fc/*analysis/*genetics

Adult

Cell Count

Gene Expression

Cytokines/genetics

Oligonucleotide Array Sequence Analysis

Lipid Metabolism/immunology

Immunoglobulins/*genetics

Receptors

Författare

Jenny Palming

Göteborgs universitet

Britt Gabrielsson

Göteborgs universitet

Eva Jennische

Göteborgs universitet

Ulf Smith

Göteborgs universitet

Björn Carlsson

Göteborgs universitet

Lena M S Carlsson

Göteborgs universitet

Malin Lönn

Göteborgs universitet

Biochemical and Biophysical Research Communications

0006-291X (ISSN) 1090-2104 (eISSN)

Vol. 343 43-8

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

DOI

10.1016/j.bbrc.2006.02.114

PubMed

16527253