A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Artikel i vetenskaplig tidskrift, 2018

© 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.

Författare

Lea B.S. Hansen

Danmarks Tekniske Universitet (DTU)

Henrik M. Roager

Köpenhamns universitet

Danmarks Tekniske Universitet (DTU)

Nadja B. Søndertoft

Köpenhamns universitet

Rikke J. Gøbel

Köpenhamns universitet

M. Kristensen

Köpenhamns universitet

Mireia Vallès-Colomer

KU Leuven

Flanders Interuniversity Institute for Biotechnology

Sara Vieira-Silva

KU Leuven

Flanders Interuniversity Institute for Biotechnology

Sabine Ibrügger

Köpenhamns universitet

Mads Vendelbo Lind

Köpenhamns universitet

Rasmus B. Mærkedahl

Köpenhamns universitet

Martin I. Bahl

Danmarks Tekniske Universitet (DTU)

M. L. Madsen

Köpenhamns universitet

Jesper Havelund

University of Southern Denmark

Gwen Falony

Flanders Interuniversity Institute for Biotechnology

KU Leuven

Inge Tetens

Köpenhamns universitet

Trine Nielsen

Köpenhamns universitet

Kristine H. Allin

Köpenhamns universitet

Henrik L. Frandsen

Danmarks Tekniske Universitet (DTU)

Bolette Hartmann

Köpenhamns universitet

Jens Juul Holst

Köpenhamns universitet

Morten H. Sparholt

Bispebjerg Hospital

Jesper Holck

Danmarks Tekniske Universitet (DTU)

Andreas Blennow

Köpenhamns universitet

Janne Marie Moll

Danmarks Tekniske Universitet (DTU)

Anne S. Meyer

Danmarks Tekniske Universitet (DTU)

Camilla Hoppe

Danmarks Tekniske Universitet (DTU)

Jørgen H. Poulsen

Hvidovre Hospital

Vera Carvalho

Danmarks Tekniske Universitet (DTU)

Domenico Sagnelli

Köpenhamns universitet

Marlene D. Dalgaard

Danmarks Tekniske Universitet (DTU)

Anders F. Christensen

Bispebjerg Hospital

Magnus Christian Lydolph

Statens Serum Institut

Alastair Ross

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

S.G.R. Villas-Bôas

University of Auckland

Susanne Brix

Danmarks Tekniske Universitet (DTU)

T. Sicheritz-Pontén

Danmarks Tekniske Universitet (DTU)

Karsten Buschard

Rigshospitalet

Allan Linneberg

Research Centre for Prevention and Health

Jüri J. Rumessen

Amtssygehuset i Gentofte

Claus T. Ekstrøm

Köpenhamns universitet

Christian Ritz

Köpenhamns universitet

Karsten Kristiansen

Köpenhamns universitet

H. Bjørn Nielsen

Clinical-Microbiomics A/S

H. Vestergaard

Köpenhamns universitet

Nils J. Færgeman

University of Southern Denmark

Jeroen Raes

Flanders Interuniversity Institute for Biotechnology

KU Leuven

Hanne Frøkiær

Köpenhamns universitet

Torben Hansen

Köpenhamns universitet

L. Lauritzen

Köpenhamns universitet

Ramneek Gupta

Danmarks Tekniske Universitet (DTU)

Tine Rask Licht

Danmarks Tekniske Universitet (DTU)

O. B. Pedersen

Köpenhamns universitet

Nature Communications

2041-1723 (ISSN)

Vol. 9 1 4630

Ämneskategorier

Livsmedelsvetenskap

Klinisk vetenskap

Näringslära

DOI

10.1038/s41467-018-07019-x

PubMed

30425247

Mer information

Senast uppdaterat

2018-11-27