Gut microbiota dysbiosis is associated with malnutrition and reduced plasma amino acid levels: Lessons from genome-scale metabolic modeling
Artikel i vetenskaplig tidskrift, 2018

Malnutrition is a severe non-communicable disease, which is prevalent in children from low-income countries. Recently, a number of metagenomics studies have illustrated associations between the altered gut microbiota and child malnutrition. However, these studies did not examine metabolic functions and interactions between individual species in the gut microbiota during health and malnutrition. Here, we applied genome-scale metabolic modeling to model the gut microbial species, which were selected from healthy and malnourished children from three countries. Our analysis showed reduced metabolite production capabilities in children from two low-income countries compared with a high-income country. Additionally, the models were also used to predict the community-level metabolic potentials of gut microbes and the patterns of pairwise interactions among species. Hereby we found that due to bacterial interactions there may be reduced production of certain amino acids in malnourished children compared with healthy children from the same communities. To gain insight into alterations in the metabolism of malnourished (stunted) children, we also performed targeted plasma metabolic profiling in the first 2 years of life of 25 healthy and 25 stunted children. Plasma metabolic profiling further revealed that stunted children had reduced plasma levels of essential amino acids compared to healthy controls. Our analyses provide a framework for future efforts towards further characterization of gut microbial metabolic capabilities and their contribution to malnutrition.

Bacterial interactions

Genome-scale metabolic modeling

Child malnutrition

Metabolic capabilities

Gut microbiota

Plasma metabolic profiling


Manish Kumar

Chalmers, Biologi och bioteknik, Systembiologi

Boyang Ji

Chalmers, Biologi och bioteknik, Systembiologi

Parizad Babaei

Chalmers, Biologi och bioteknik, Systembiologi

Promi Das

Chalmers, Biologi och bioteknik, Systembiologi

Dimitra Lappa

Chalmers, Biologi och bioteknik, Systembiologi

Girija Ramakrishnan

University of Virginia

Todd E. Fox

University of Virginia

Rashidul Haque

International Centre for Diarrhoeal Disease Research Bangladesh

William A. Petri

University of Virginia

Fredrik Bäckhed

Köpenhamns universitet

Göteborgs universitet

Jens B Nielsen

Danmarks Tekniske Universitet (DTU)

Chalmers, Biologi och bioteknik, Systembiologi

Metabolic Engineering

1096-7176 (ISSN) 1096-7184 (eISSN)

Vol. 49 128-142



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